| 骆思宏
，张成宇
，郑宇彤
，李晓宁.食欲素治疗抑郁失眠共病的研究进展[J].神经损伤功能重建,2024,(9):541-545 |
| 食欲素治疗抑郁失眠共病的研究进展 |
| Research Progress on Orexin Treatment for Comorbid Depression and Insomnia |
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| DOI： |
| 中文关键词: 食欲素 失眠 抑郁 共病 |
| 英文关键词: orexin insomnia depression comorbidity |
| 基金项目: |
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| 摘要点击次数: 706 |
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| 中文摘要: |
| 抑郁是以心情低落为主要特征的一种常见精神疾病，在临床实际接触中抑郁患者往往伴有失眠症
状，尤其是在经历过新冠肺炎疫情大流行后，生活和工作的双重压力下失眠及抑郁更是当下常见的精神障
碍类疾病，往往是两种症候并存。以往的治疗中抗抑郁、抗失眠药物联合使用可以达到治疗抑郁失眠的作
用，但副作用大，使用限制多，故研究两者共同靶点，寻找抑郁失眠共病新治疗方法是当下急需的。本文围
绕食欲素及其受体信号通路、脑区分布等方面探析，综合论述食欲素与失眠、抑郁共病之间的联系及可能
涉及的作用靶点、机制通路，思考从食欲素治疗抑郁失眠共病的可能性，以期为食欲素的开发与应用提供
参考，更好地解决抑郁失眠共病问题。 |
| 英文摘要: |
| Depression is a common mental disorder primarily characterized by a persistent low mood.
Clinically, patients with depression often suffer from insomnia, which has become more prevalent since the
COVID-19 pandemic due to the dual pressures of life and work. Insomnia and depression frequently cooccur as
dual symptoms. Traditional treatments involving a combination of antidepressant and anti-insomnia medications
can be effective, but they have significant adverse effects and numerous usage limitations. Therefore, there is an
urgent need for research into the shared targets of both conditions and the development of new therapeutic
approaches for comorbid depression and insomnia. This review explores the role of orexin, its receptor signaling
pathway and its distribution in the brain, and discusses the connections between orexin and the comorbidity of
insomnia and depression, along with potential targets and mechanisms. This article highlights the possibility of
orexin in treating comorbid depression and insomnia, aiming to provide a reference for the development and
application of orexin, and to better address the issue of comorbid depression and insomnia. |
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