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| 婴幼儿时期全身麻醉手术暴露对学龄期儿童注意力的影响分析 |
| Effects of general anesthesia exposure during infants aged 0-2 years on cognitive and behavioral neurodevelopment of school-age children |
| 投稿时间：2024-09-06 修订日期：2024-09-06 |
| DOI： |
| 中文关键词: 全身麻醉暴露 婴幼儿 注意力缺陷 |
| 英文关键词: general anesthesia exposure infants attention deficit |
| 基金项目:儿童注意缺陷多动障碍精准诊疗体系的建立和应用 |
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| 中文摘要: |
| 目的：探讨0~2岁婴幼儿期接受全身麻醉手术是否会对学龄期儿童注意力产生影响。方法：本研究选取2009年6月至2013年12月间在南京市儿童医院就诊的0~2岁时接受全身麻醉手术的学龄儿童为暴露组，匹配未接触全身麻醉的健康儿童为对照组。受试儿童接受标准化注意力测试及家长问卷调查。暴露组按首次暴露年龄、暴露时间及次数分组。主要评估指标为整合视听连续执行测试（IVA-CPT）与SNAP-IV评定量表。结果：注意力不足、听觉速度商数、视觉持续性商数与出生时孕周、暴露次数、首次暴露年龄、首次麻醉时间显著相关。听觉感觉/运动商数与出生时孕周、居住地、暴露次数、首次暴露年龄以及首次麻醉时间显著相关。视觉感觉/运动商数与是否单胎、暴露次数、首次暴露年龄以及首次麻醉时间显著相关。听觉注意力商数与出生时孕周、是否单胎、暴露次数、首次暴露年龄以及首次麻醉时间显著相关。结论：0-2岁婴幼儿期接受全身麻醉对学龄期儿童的注意力发育有影响，多次麻醉影响更显著。 |
| 英文摘要: |
| Objective: This study aims to investigate whether exposure to general anesthesia during surgery in infants aged 0-2 years has an impact on cognitive and behavioral neurodevelopment in school-age children.
Methods: This study selected school-age children who underwent general anesthesia surgery at the age of 0-2 at our medical center from June 2009 to December 2013 as the exposed group, and matched healthy children who had not been exposed to general anesthesia as the control group. The subjects underwent standardized neurological testing and a parental questionnaire survey. The exposed group was grouped according to the age of first exposure, duration of exposure, and number of exposures. The primary assessment indicators were the Integrated Visual and Auditory Continuous Performance Test (IVA-CPT) and the SNAP-IV rating scale.ResultsAttention deficiency, auditory speed quotient, and visual persistence quotient significantly correlate with gestational weeks at birth, anesthesia exposures, age at first exposure, and duration of first anesthesia. Auditory sensory/motor quotient correlates with these factors, plus residence. Visual sensory/motor quotient and auditory attention quotient correlate with single/multiple birth status and the aforementioned factors.
Conclusion:"Receiving general anesthesia during infancy (0-2 years old) has an impact on the attention development of school-age children, and multiple anesthetics have a more significant effect." |
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