| 段冰玉，刘丹，张肖，许黎，王贺.武汉地区不同新冠毒株导致化学感受器功能障碍的比较[J].神经损伤功能重建,2024,(9):524-530 |
| 武汉地区不同新冠毒株导致化学感受器功能障碍的比较 |
| Comparison of Chemosensory Dysfunction In Patients with Covid-19 Caused By DifferentStrain of SARS-CoV-2 In Wuhan |
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| DOI： |
| 中文关键词: 嗅觉 味觉 新型冠状病毒 奥密克戎 |
| 英文关键词: olfactory gustatory Coronavirus Omicron |
| 基金项目: |
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| 中文摘要: |
| 目的：比较不同毒株SARS-Cov-2感染后的COVID-19特征，特别是对味觉和嗅觉的影响。方法：选
取武汉市43例由奥密克戎感染引起的住院患者，与武汉原始毒株感染的COVID-19患者进行倾向值匹配，
比较2组患者的临床特征和实验室资料。结果：与原始毒株组相比，奥密克戎组患者合并糖尿病、恶性肿瘤
等基础疾病和吸烟史的可能性更高。奥密克戎组患者更易出现疲劳、呼吸短促、咳嗽、鼻塞、鼻漏等症状。
2组间嗅觉障碍和味觉障碍发生率差异无统计学意义。有味觉障碍的患者血清白介素-6和白介素-8低于
无味觉障碍的患者。结论：奥密克戎感染的患者相关基础疾病较多。在住院患者中由奥密克戎引起的化
学感受器功能障碍的发生率与原毒株相似。 |
| 英文摘要: |
| To compare different clinical features and laboratory data of infection of different
variants of SARS-CoV-2, especially the impact on the sense of smell and taste. Methods: Forty-three
hospitalized COVID-19 patients caused by Omicron variant (Omicron group) in Wuhan was enrolled. A
previous published cohort of hospitalized COVID-19 patients (original group) during the first pandemic in
Wuhan were age, sex, and disease severity-matched to the Omicron group in a ratio of 1∶1. The clinical features
and laboratory data were compared between groups. Results: Patients in Omicron group were more likely to be
comorbid with diabetes, malignancy and smoking history compared to original group. More patients in Omicron
group complained fatigue, short of breath, cough, nasal obstruction and rhinorrhea. No significant difference in
the incidence of olfactory dysfunction or gustatory dysfunction was found between groups. The serum IL-6 and
IL-8 were lower in patients with gustatory dysfunction compared to those without gustatory dysfunction.
Conclusion: Hospitalized COVID-19 patients caused by Omicron variant are with more comorbidities. The
incidence of chemosensory dysfunction was similar in the hospitalized patients caused by Omicron and original
strain. |
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