| 张一博,
，孙新刚.小胶质细胞极化在蛛网膜下腔出血早期脑损伤中的作用机制研究进展[J].神经损伤功能重建,2024,(8):478-482 |
| 小胶质细胞极化在蛛网膜下腔出血早期脑损伤中的作用机制研究进展 |
| Research Progress on the Role of Microglia Polarization in Early Brain Injury afterSubarachnoid Hemorrhage |
| |
| DOI： |
| 中文关键词: 蛛网膜下腔出血 早期脑损伤 小胶质细胞 神经炎症 |
| 英文关键词: subarachnoid hemorrhage early brain injury microglia neuroinflammation |
| 基金项目:山西省科学技术厅
自然科学面上项目
（mTOR/Hif-1á介导
蛛网膜下腔出血后
早期脑损伤中 M1
型小胶质细胞激活
的代谢途径研究，
No. 202103021236
4）；山西省卫生健
康委员会科研课题
（TREM-1 调 控 蛛
网膜下腔出血后炎
症级联反应形成的
机制研究，No. 201
9045） |
|
| 摘要点击次数: 1117 |
| 全文下载次数: 2492 |
| 中文摘要: |
| 蛛网膜下腔出血（subarachnoid hemorrhage，SAH）是神经系统的急危重症，常有不良预后。临床研究
发现早期脑损伤（early brain injury，EBI）广泛存在于SAH患者中，可能是造成预后不良的重要原因。临床
前研究在了解EBI的机制方面取得了进展，小胶质细胞是参与EBI的主要细胞成分。EBI中的神经炎症主
要由M1型小胶质细胞驱动，参与血脑屏障破坏和神经元死亡；此外，M2表型小胶质细胞表现出减轻脑水
肿和改善神经功损伤的功能。因此，阐明SAH后小胶质细胞的极化及参与EBI的途径对干预SAH神经炎
症反应具有重要意义。 |
| 英文摘要: |
| Subarachnoid hemorrhage (SAH) is a critical emergency in neurology, often associated with poor
prognosis. Clinical studies have found that early brain injury (EBI) is widespread among SAH patients and may
be a significant cause of poor outcomes. Preclinical research has made progress in understanding the mechanisms of EBI, with microglia being a major cellular component involved. The neuroinflammation in EBI is primarily driven by M1-type microglia, which participate in the disruption of the blood-brain barrier and neuronal
death; additionally, M2-phenotype microglia exhibit functions that alleviate cerebral edema and improve neurological damage. Therefore, elucidating the polarization of microglia after SAH and their involvement in EBI
pathways is of great significance for intervening in the neuroinflammatory response to SAH. |
|
查看全文
查看/发表评论 下载PDF阅读器 |
| 关闭 |