| 廖清睿,
，程凯倩,
，刘培欣,
，梅靖宇,
，朱钊
，黄淑玉
，吴敏.维生素D、血小板与淋巴细胞比值在2型糖尿病周围神经病变中的意义[J].神经损伤功能重建,2024,(8):457-461 |
| 维生素D、血小板与淋巴细胞比值在2型糖尿病周围神经病变中的意义 |
| The Significance of Serum Vitamin D, Platelet to Lymphocyte Ratio in Peripheral Neuropathyof Type 2 Diabetes Mellitus |
| |
| DOI： |
| 中文关键词: 维生素D 血小板与淋巴细胞比值 2型糖尿病周围神经病变 25羟基维生素D |
| 英文关键词: vitamin D platelet to lymphocyte ratio type 2 diabetic peripheral neuropathy 25-hydroxyvitamin D |
| 基金项目:2023 年 度 职 业 危
害识别与控制湖北
省重点实验室联合
基金项目（医务人
员维生素 D 水平
与代谢综合征发生
风险及其相关代谢
组分聚集性分析，
No. JF2023-K04） |
|
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| 中文摘要: |
| 目的：探讨维生素D、血小板与淋巴细胞比值（platelet to lymphocyte ratio，PLR）与2型糖尿病周围神
经病变（diabetic peripheral neuropathy，DPN）的相关性。方法：选取2021年8月至2023年1月在武汉科技大
学附属孝感医院内分泌科住院的2型糖尿病患者256例为研究对象，依据是否并发DPN将其分为2组：单
纯2型糖尿病124例纳入对照组，2型糖尿病合并DPN 132例纳入观察组。测量患者血压、身高、体质量等；
检测患者血常规、血糖、血脂、糖化血红蛋白（HbA1c）、血清25羟基维生素D[25(OH)D]等生化指标，并计算
PLR；比较2组PLR、25(OH)D及其他指标之间的差异，运用Logistic回归分析以明确影响DPN发生的独立
危险因素，Pearson相关性分析明确PLR与血清25(OH)D及其他生化指标的相关性。结果：观察组年龄、糖
尿病病程、收缩压、血小板计数、空腹血糖、HbA1c、低密度脂蛋白胆固醇（high-density lipoprotein cholesterol，HDL-C）、甘油三酯（triglyceride，TG）、PLR均高于对照组；高密度脂蛋白胆固醇（high-density lipoprotein
cholesterol，HDL-C）、淋巴细胞计数、血清25(OH)D低于对照组；差异均具有统计学意义（P＜0.05）；Logistic
回归分析结果显示 PLR、年龄、糖尿病病程、HbA1c、LDL-C 为 2 型糖尿病患者 DPN 发生的危险因素，25
(OH)D 为 2 型糖尿病患者 DPN 的保护因素（P＜0.05）；当血清 25(OH)D＜31.72 ng/mL 时，可以有效提示
DPN的发生风险（P＜0.05）；Pearson相关性分析发现PLR与年龄、糖尿病病程、体质量指数、收缩压、空腹血
糖、HbA1c、LDL-C、TG 呈正相关（P＜0.05）；与 HDL-C、血清 25(OH)D 呈负相关（P＜0.05）。结论：PLR 为
DPN发生的危险因素之一，维生素D为DPN的保护性因素，且PLR与维生素D水平负相关。 |
| 英文摘要: |
| To investigate the relationship between serum vitamin D levels, platelet-to-lymphocyte
ratio (PLR), and peripheral neuropathy in patients with type 2 diabetes mellitus (DPN). Methods: A total of
256 patients with type 2 diabetes mellitus who were hospitalized from August 2021 to January 2023 at the Endocrinology Department of Xiaogan Hospital affiliated with Wuhan University of Science and Technology were selected as research subjects. Based on whether they had DPN, they were divided into two groups: 124 cases with
simple type 2 diabetes mellitus were included in the control group, and 132 cases with type 2 diabetes mellitus
complicated by DPN were included in the observation group. The patients’blood pressure, height, and body
mass index were measured; routine blood tests, blood glucose, lipid profiles, glycosylated hemoglobin (HbA1c),
serum 25-hydroxyvitamin D [25(OH)D], and other biochemical indicators were tested, and the PLR was calculated; the differences between the two groups in PLR, 25(OH)D, and other indicators were compared. Logistic
regression analysis was used to identify independent risk factors for the development of DPN, and Pearson correlation analysis was used to determine the correlation between PLR and serum 25(OH)D, as well as other biochemical indicators. Results: The observation group had higher ages, duration of diabetes, systolic blood pressure, platelet count, fasting blood glucose, HbA1c, low-density lipoprotein cholesterol (HDL-C), triglycerides
(TG), and PLR than the control group; high-density lipoprotein cholesterol (HDL-C), lymphocyte count, and serum 25(OH)D were lower than the control group; all differences were statistically significant (P<0.05). Logistic
regression analysis showed that PLR, age, duration of diabetes, HbA1c, and LDL-C were risk factors for the development of DPN in patients with type 2 diabetes mellitus, while vitamin D was a protective factor against
DPN (P<0.05); when serum 25(OH)D < 31.72 ng/mL, it could effectively indicate the risk of developing DPN
(P<0.05); Pearson correlation analysis found that PLR was positively correlated with age, duration of diabetes,
body mass index, systolic blood pressure, fasting blood glucose, HbA1c, LDL-C, and TG (P<0.05); but negative-
ly correlated with HDL-C and serum 25(OH)D (P<0.05). Conclusion: PLR is one of the risk factors for the development of DPN, while
vitamin D is a protective factor against DPN. Moreover, PLR is negatively correlated with vitamin D levels. |
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