|
| 铁死亡在多发性硬化中诱导炎性脱髓鞘概述 |
| Overview of ferroptosis-induced inflammatory demyelination in multiple sclerosis |
| 投稿时间：2024-07-14 修订日期：2024-07-14 |
| DOI： |
| 中文关键词: 多发性硬化 铁死亡 神经炎症 脱髓鞘 |
| 英文关键词: multiple sclerosis, ferroptosis, neuroinflammation, demyelination |
| 基金项目:国家自然科学基金（No.8236025）；甘肃省中医药管理局(No.GZKP-2022-34)；甘肃省教育科技创新项目（2022B-028） |
|
| 摘要点击次数: 50 |
| 全文下载次数: 0 |
| 中文摘要: |
| 铁死亡(Ferroptosis)是一种铁依赖性磷脂过氧化、活性氧自由基大量堆积所导致的细胞死亡模式。多项研究表明,各种细胞铁死亡与多发性硬化(Multiple Sclerosis,MS)炎症浸润以及脱髓鞘等病理过程密切相关。本文主要概述了近些年铁死亡在MS神经炎症和脱髓鞘中T细胞,小胶质细胞,少突胶质细胞作用,旨在从铁死亡的角度探究MS的发病机制,通过靶向铁死亡的方式拓展临床治疗策略,为MS的有效防治提供新的神经保护剂。 |
| 英文摘要: |
| Ferroptosis is a cell death pattern caused by iron-dependent phospholipid peroxidation and large accumulation of reactive oxygen species. A number of studies have shown that various cellular ferroptosis are closely related to multiple sclerosis (MS), inflammatory infiltration and demyelination. This article mainly summarizes the role of ferroptosis in MS neuroinflammation and demyelination in recent years, with the aim of exploring the pathogenesis of MS from the perspective of ferroptosis, expanding clinical treatment strategies by targeting ferroptosis, and providing new neuroprotective agents for the effective prevention and treatment of MS. |
|
View Fulltext
查看/发表评论 下载PDF阅读器 |
| 关闭 |