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| 小胶质细胞极化在癫痫中的研究进展 |
| Research Advances on Microglial Polarization in Epilepsy |
| 投稿时间：2024-07-11 修订日期：2024-07-11 |
| DOI： |
| 中文关键词: 癫痫 小胶质细胞 炎性极化 免疫微环境 |
| 英文关键词: Epilepsy Microglia Inflammatory Polarization Immune Microenvironment |
| 基金项目:武汉市卫健委科研项目（立项编号：WX21B25）, |
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| 中文摘要: |
| 癫痫是一种因脑神经元异常放电而引起的神经系统疾病,全球大约有5000万人受其影响。近年来,小胶质细胞——中枢神经系统内固有的免疫细胞——在癫痫病理学中的角色引起了广泛关注。本综述基于最新研究成果,探讨了小胶质细胞的炎性极化及其在癫痫中的双重作用,包括M1型小胶质细胞的促炎损伤作用和M2型小胶质细胞的抗炎保护作用。文章还讨论了小胶质细胞极化与细胞焦亡、自噬、线粒体功能障碍及细胞铁死亡等其他细胞功能间的相互关系。目前,小胶质细胞不同细胞功能间的相互作用及其与其他脑细胞间复杂的关联在癫痫病理机制中的确切作用仍待进一步研究明确。通过概述小胶质细胞极化在癫痫病理学中的最新研究进展,本文探讨了其在治疗上的潜在价值和面临的挑战,为将来的研究方向提供了思路。 |
| 英文摘要: |
| Epilepsy is a neurological disorder caused by abnormal neuronal discharges, affecting approximately 50 million people worldwide. In recent years, microglia, the intrinsic immune cells of the central nervous system, have garnered widespread attention for their role in the pathophysiology of epilepsy. This review, based on the latest research findings, discusses the inflammatory polarization of microglia and their dual role in epilepsy, including the pro-inflammatory damaging effects of M1 polarization and the anti-inflammatory protective effects of M2 polarization. It also examines the interplay between microglial polarization and other cellular functions such as cell pyroptosis, autophagy, mitochondrial dysfunction, and ferroptosis. Currently, the exact role of the complex interactions between different microglial functions and their association with other brain cells in the pathological mechanism of epilepsy remains to be further clarified through in-depth research. By summarizing the cutting-edge research on microglial polarization in the pathophysiology of epilepsy, this article explores its potential therapeutic value and challenges, providing insights for future research directions. |
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