文章摘要
卒中后睡眠障碍患者临床特征及与卒中复发风险的相关性探讨
Exploration into the clinical characteristics of patients with post-stroke sleep disorders and their correlation with the risk of stroke recurrence
投稿时间:2024-07-10  修订日期:2024-07-10
DOI:
中文关键词: 脑卒中  睡眠障碍  临床特征  复发风险  神经功能缺损程度  相关性
英文关键词: Stroke  sleep disturbance  Clinical characteristics  Risk of recurrence  Degree of neurological deficit  Correlation
基金项目:
作者单位邮编
张海燕 沧州市人民医院 061000
王宁宁 沧州市人民医院 
冯晨芳 沧州市人民医院 
张明月 沧州市人民医院 
左美美 沧州市人民医院 
陶瑞明 沧州市人民医院 061000
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中文摘要:
      目的 探讨分析卒中后伴与不伴睡眠障碍患者的临床特征,并分析其临床特征与卒中复发风险的相关性,为临床防治提供参考依据。方法 选取2021年9月~2023年7月本院246例卒中后睡眠障碍患者作为睡眠障碍组,同期230例卒中后无睡眠障碍患者作为无睡眠障碍组,对比两组临床特征及卒中复发率,比较睡眠障碍组不同临床特征患者卒中复发风险。结果 两组年龄、性别、高血压、糖尿病、高血脂症、饮酒史、习惯性打鼾、卒中类型、卒中部位、神经功能缺损程度差异有统计学意义(P<0.05);随访半年,卒中后睡眠障碍患者卒中复发率24.80%(61/246)高于卒中后无睡眠障碍患者6.96%(16/230)(χ2=27.900,P<0.05);经RR的假设检验,卒中后睡眠障碍患者与卒中后无睡眠障碍患者的卒中复发风险比较,差异有统计学意义(U=4.836,P<0.05);睡眠障碍组复发、未复发患者年龄、既往慢性病史、既往慢性病史、饮酒史、习惯性打鼾、卒中类型、卒中部位、神经功能缺损程度比例比较,差异有统计学意义(P<0.05);列联相关性分析显示,年龄、饮酒史、习惯性打鼾、合并高血压、糖尿病、高脂血症、缺血性卒中、基底节区卒中与卒中复发风险呈正相关(P<0.05);Spearman相关性分析显示,神经功能缺损程度与卒中复发风险呈正相关(P<0.05)。结论 卒中后睡眠障碍与卒中复发风险呈正相关,年龄、饮酒史、习惯性打鼾、合并高血压、糖尿病、高脂血症、缺血性卒中、基底节区卒中、神经功能缺损程度与卒中复发风险呈正相关,临床应依据睡眠障碍特征,制定相应防治方案,以降低卒中复发风险。
英文摘要:
      Objective To explore the clinical characteristics of patients with and without sleep disorders after stroke, and analyze the correlation between their clinical characteristics and the risk of stroke recurrence, in order to provide reference for clinical prevention and treatment. Methods A total of 246 patients with post-stroke sleep disorders from September 2021 to July 2023 were selected as the sleep disorder group, and 230 patients without sleep disorders after stroke were selected as the non-sleep disorder group. The clinical characteristics and stroke recurrence rates of the two groups were compared, and the stroke recurrence risk of patients with different clinical characteristics in the sleep disorder group was compared. Results There were significant differences in age, sex, hypertension, diabetes, hyperlipidemia, drinking history, habitual snoring, stroke type, stroke site, and degree of neurological impairment between the two groups (P<0.05); following up for six months, the recurrence rate of stroke in patients with post-stroke sleep disorders was 24.80% (61/246), which was higher than that in patients without post-stroke sleep disorders at 6.96% (16/230)( χ2=27.900, P<0.05); According to the hypothesis test of RR, there was a statistically significant difference in the risk of stroke recurrence between patients with post-stroke sleep disorders and those without post-stroke sleep disorders (U=4.836, P<0.05); there was a statistically significant difference in the proportion of recurrent and non recurrent patients with sleep disorders, including age, history of chronic diseases, history of chronic diseases, history of alcohol consumption, habitual snoring, stroke type, stroke site, and degree of neurological deficits (P<0.05); contingent correlation analysis showed that age, drinking history, habitual snoring, hypertension, diabetes, hyperlipidemia, ischemic stroke, basal ganglia stroke were positively correlated with the risk of stroke recurrence (P<0.05); Spearman correlation analysis showed that the degree of neurological deficits was positively correlated with the risk of stroke recurrence (P<0.05). Conclusion Post stroke sleep disorder is positively correlated with the risk of stroke recurrence. Age, drinking history, habitual snoring, hypertension, diabetes, hyperlipidemia, ischemic stroke, basal ganglia stroke, and degree of neurological impairment are positively correlated with the risk of stroke recurrence. Clinical treatment should be based on the characteristics of sleep disorder and formulate corresponding prevention and treatment programs to reduce the risk of stroke recurrence.
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