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| 电针治疗中枢神经系统疾病的免疫炎症机制探讨 |
| Study on Immunoinflammatory Mechanism of Electroacupuncture in the Treatment of Central Nervous System Diseases |
| 投稿时间：2024-07-09 修订日期：2024-07-09 |
| DOI： |
| 中文关键词: 电针 中枢神经系统 免疫系统 神经炎症 |
| 英文关键词: Electroacupuncture Central nervous system Immune system Neuroinflammation |
| 基金项目:黑龙江省博士后面上项目（项目编号LBH-Z22280）； 国家自然科学基金面上项目（项目编号81873378） |
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| 中文摘要: |
| 中枢神经系统(central nervous system, CNS)的广泛免疫反应包括先天免疫反应和适应性免疫反应，涉及多种免疫效应细胞参与。过度免疫诱导的神经炎症是大多数神经系统疾病的关键过程，包括神经退行性疾病如阿尔茨海默病(alzheimer's disease, AD)、帕金森病(parkinson 's disease, PD)，同时在脑血管疾病(cerebrovascular disease,CVD)、脊髓损伤(spinal cord injury,SCI)和多发性硬化（multiple sclerosis,MD）等继发损伤的病理过程中，其危害性甚至超过原发损伤。目前针对CNS疾病的神经免疫治疗多以药物为主，如环孢素A、皮质类固醇、甲基强的松龙、米诺环素等，电针作为绿色疗法具有副作用少、安全性高的特点，且治疗上述CNS疾病疗效已被确切证实，但治疗作用包含的生物学机制较为复杂，如调节神经递质、改善或优化肠道菌群、调节免疫、缓解氧化应激等方面。本文从神经免疫系统激活诱导神经炎症方向切入，总结近年来CNS疾病中起主要作用的免疫效应细胞类型，并阐述免疫细胞的作用机理，探讨电针如何通过调控神经-免疫系统和免疫细胞抑制神经炎症，从而达到治疗疾病的分子生物学机制，为临床推广电针疗法增加可行性依据。 |
| 英文摘要: |
| The broad immune response of the centralnervoussystem (CNS) includes innate immune response and adaptive immune response, involving a variety of immune effector cells. Hyperimmune-induced neuroinflammation is a key process in most neurological diseases, including neurodegenerative diseases such as alzheimer'sdisease (AD), parkinson'sdisease (PD), At the same time in cerebrovascular disease (cerebrovasculardisease, CVD), spinal cord injury (spinalcordinjury, SCI) and secondary injury such as multiple sclerosis (multiplesclerosis, MD) pathological process, even more damaging than the primary damage. At present, the neuroimmunotherapy for CNS diseases mainly focuses on drugs, such as cyclosporine A, corticosteroids, methylprednisolone, minocycline, etc. Electroacupuncture, as a green therapy, has the characteristics of few side effects and high safety, and the therapeutic effect in the treatment of the above-mentioned CNS diseases has been confirmed, but the biological mechanism involved in the therapeutic effect is more complex.It includes regulating neurotransmitters, improving or optimizing intestinal flora, regulating immunity, and alleviating oxidative stress. Starting from neuroinflammation induced by neuroimmune system activation, this paper summarizes the types of immune effector cells that play a major role in CNS diseases in recent years, describes the mechanism of immune cells, and discusses the molecular biological mechanism of how electroacupuncture can inhibit neuroinflammation by regulating the neuro-immune system and immune effector cells to treat diseases.To increase the feasibility basis for clinical promotion of electroacupuncture therapy. |
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