| Objective: To investigate the correlation between chronic kidney disease and cognitive impairment in the elderly.Methods:A total of 102 patients with chronic kidney disease over 80 years old who were hospitalized in the geriatric department of our hospital from January 2022 to June 2023 were retrospectively selected.According to MoCA score, 65 patients were divided into cognitive impairment group and 37 patients were divided into normal cognitive function group。At the same time,we detect urine AD7c-NTP, MNA-SF, Pittsburgh Sleep Quality Index, urea, creatinine, uric acid, urinary protein/urinary creatinine ratio,HOMA-IR and proceed statistical analysis.Results:Compared with the two groups, there were no statistical differences in age and sex(P > 0.05), but there were significant differences in MoCA and AD7c-NTP (P < 0.05), and there were no statistical differences in uric acid and HOMA-IR (P > 0.05). There were significant differences in urea, creatinine, ACR, Hcy, MNA-SF and PSQI (P < 0.05). Correlation study analysis showed that AD7c-NTP was correlated with urea, creatinine, ACR and MNA-SF (P < 0.05), and was positively correlated with urea, creatinine and ACR, but negatively correlated with MNA-SF. There was correlation between MoCA and urea, creatinine, ACR, MNA-SF and Hcy (P < 0.05), positive correlation between MOCA and MNA-SF and negative correlation between MOCA and urea, creatinine, ACR and HCY. Binary logistic regression analysis showed that urea, ACR, MNA-SF and PSQI were correlated with cognitive impairment (P < 0.05).Conclusion:Increased urea and ACR levels, malnutrition, and Sleep disorder can lead to cognitive impairment in elderly patients with chronic kidney disease |