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| 基于3DsMRI分析AD源性MCI及AD患者脑灰质体积的改变与认知损害的相关性 |
| The correlation between the change of gray matter volume and cognitive impairment in patients with AD-derived MCI and AD was analyzed based on 3DsMRI |
| 投稿时间：2024-06-16 修订日期：2024-06-16 |
| DOI： |
| 中文关键词: 遗忘型轻度认知功能障碍 阿尔茨海默病 磁共振成像 体素形态学测量 表面形态学测量 |
| 英文关键词: Forgetting mild cognitive impairment Alzheimer""s disease Magnetic resonance imaging Voxel morphology measurement Surface morphology measurement |
| 基金项目:]：海南省自然科学基金-高层次人才项目(821RC1121)；海南省自然科学基金青年(821QN0987)；海南省临床医学中心建设项目(2021) |
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| 中文摘要: |
| 目的：探讨遗忘型轻度认知功能障碍(amnestic mild cognitive impairment,aMCI)和阿尔茨海默病(Alzheimer"s disease, AD)患者与正常老年人在灰质体积和皮层厚度上的差异,分析其与认知水平之间的关系,为临床诊断aMCI及早期AD提供依据。方法：前瞻性纳入aMCI患者23例、AD患者22例及正常对照(Healthy control, HC)组23例,对所有受试者进行脑结构MRI(structural MRI, sMRI)扫描,使用CAT12的Segment功能对3D-T1MRI图像行基于体素的形态学测量(Voxel-based morphometry, VBM)和表面形态学测量(Surface-based Morphometry,SBM),获得所有受试者特定脑区的灰质体积及皮层厚度。并运用神经心理学量表进行认知功能评测。分析3组间主要结构灰质体积、皮层厚度的差异,从差异脑区中提取感兴趣区(region of interest,ROI)并探究其与认知量表评分的相关性。 结果：3组间方差分析及多重比较结果显示在多个脑区存在差异(FWE校正,P<0.05),差异脑区体积与MoCA量表有明显相关性(P<0.05)；且不同脑区体积与认知域的相关性大小有明显差异(P<0.05)。结论：aMCI及AD患者脑灰质体积及脑皮层存在不均匀分布的减小。左侧海马、嗅皮质、脑岛的提前萎缩可能是影响AD患者早期认知功能的原因。对特定脑区定量测量可以辅助临床早期识别aMCI和早期AD患者,为AD的诊断及早期治疗干预提供有效依据。 |
| 英文摘要: |
| Objective Exploring the differences in gray matter volume and cortical thickness between patients with amnestic mild cognitive impairment (aMCI) and Alzheimer"s disease (AD) and normal elderly individuals, analyzing their relationship with cognitive level, and providing a basis for clinical diagnosis of aMCI and early AD. Methods 23 aMCI patients, 22 AD patients, and 23 healthy control (NC) groups were prospectively included. Structural MRI (sMRI) scans of brain structures were performed on all subjects. The segment function of CAT12 was used to perform voxel based morphology (VBM) and surface based morphology (SBM) measurements on 3D-T1 MRI images, Obtain the gray matter volume and cortical thickness of specific brain regions for all subjects. And cognitive function assessment was conducted using neuropsychological scales. Analyze the differences in main structural gray matter volume and cortical thickness among three groups, extract regions of interest (ROI) from different brain regions, and investigate their correlation with cognitive scale scores. Results The results of analysis of variance between three groups and multiple comparison showed differences in multiple brain regions (FWE correction, P<0.05), and there was a significant correlation between the volume of different brain regions and the MoCA scale (P<0.05); And there is a significant difference in the correlation between different brain area volumes and cognitive domains (P<0.05). Conclusion There is a reduction in the uneven distribution of gray matter volume and cerebral cortex in patients with aMCI and AD. The early atrophy of the left hippocampus, olfactory cortex, and insula may be a factor affecting early cognitive function in AD patients. Quantitative measurement of specific brain regions can assist in early clinical identification of aMCI and early AD patients, providing effective conditional basis for the diagnosis and early treatment intervention of AD. |
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