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| 微环境因素调控多发性硬化髓鞘再生的作用及机制研究进展 |
| Research progress on the role and mechanism of microenvironmental factors in regulating remyelination in multiple sclerosis |
| 投稿时间：2024-05-29 修订日期：2024-05-29 |
| DOI： |
| 中文关键词: 多发性硬化 髓鞘再生 少突胶质前体细胞 微环境 小胶质细胞 |
| 英文关键词: Multiple sclerosis Remyelination Oligodendrocyte precursor cells Smicroenvironment Microglia |
| 基金项目: |
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| 中文摘要: |
| 多发性硬化(MS)病理机制复杂,目前的临床治疗措施并不能阻止病情进展且副作用较多,急需开发新的有效临床治疗措施以改善MS患者临床症状和预后。髓鞘再生可以为MS整个病程提供益处,促进髓鞘再生是一种极具潜力的MS治疗措施。少突胶质前体细胞作为负责MS髓鞘再生的细胞,其髓鞘再生能力受多种微环境因素的影响。该文首次综述固有免疫细胞、髓鞘碎片、细胞外基质、星形胶质细胞、神经元、周细胞和内皮细胞、适应性免疫细胞、外周循环和衰老等微环境因素对MS髓鞘再生的影响和机制,以期为MS的防治提供参考。 |
| 英文摘要: |
| The pathological mechanism of Multiple sclerosis (MS) is complex, and the current clinical treatment measures cannot prevent the progress of the disease and have many side effects. It is urgent to develop new effective clinical treatment measures to improve the clinical symptoms and prognosis of MS patients. Remyelination can provide benefits for the whole course of MS. Promoting remyelination is a promising treatment for MS. As the cell responsible for the remyelination of MS, The ability of remyelination of oligodendrocyte precursor cells is affected by many microenvironment factors. In this paper, the effects and mechanisms of microenvironment factors such as intrinsic immune cells, myelin debris, extracellular matrix, astrocytes, neurons, pericytes and endothelial cells, adaptive immune cells, peripheral circulation and aging on remyelination in MS are reviewed for the first time, in order to provide reference for the prevention and treatment of MS. |
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