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| rTMS对老年无功能垂体大腺瘤切除术后患者临床恢复的效果评价 |
| Evaluation of the effect of rTMS on the clinical recovery of elderly patients with non-functional pituitary macroadenoma after resection |
| 投稿时间：2024-05-28 修订日期：2024-05-28 |
| DOI： |
| 中文关键词: 重复经颅磁刺激 老年无功能垂体大腺瘤 临床症状 神经内分泌激素 疗效 |
| 英文关键词: repetitive transcranial magnetic stimulation nonfunctioning pituitary macroadenoma in the elderly clinical symptoms neuroendocrine hormones efficacy |
| 基金项目:2022年河北省自然科学基金资助项目（精准医学联合基金培育项目，No. H2022105014）；唐山市人才资助项目（编号：A202110019）；2022年度河北省中央引导地方科技发展资金项目（226Z7704G） |
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| 中文摘要: |
| 目的 探究重复经颅磁刺激（rTMS）对老年无功能垂体大腺瘤切除术后患者临床恢复及神经内分泌功能的影响。方法 回顾性将我院神经外科2022年02月至2024年02收治的48例老年无功能垂体大腺瘤患者，随机分为观察组（n=25例）与对照组（n=23例），均行神经内镜辅助下经鼻蝶窦手术治疗，观察组术后在常规临床治疗基础上进行rTMS治疗。对照组术后则按同样方式使用无磁场脉冲发射的假线圈治疗。比较两组治疗前后头痛及视力恢复、激素水平以及临床疗效情况。结果 相比术前，两组术后1个月头痛、视力改善情况及垂体激素水平均升高，且观察组优于对照组（P＜0.05），并且观察组临床疗效明显优于对照组（P＜0.05）。结论 重复经颅磁刺激对老年无功能垂体大腺瘤切除术后患者临床症状改善具有良好效果，且对于患者的神经内分泌功能恢复具有明显的促进作用，值得临床推广应用。 |
| 英文摘要: |
| Objective To explore the effect of repetitive transcranial magnetic stimulation (rTMS) on clinical recovery and neuroendocrine function of elderly patients with non-functional pituitary macroadenoma after resection. Methods A total of 48 elderly patients with non-functioning pituitary macroadenoma admitted to the Department of Neurosurgery of our hospital from February 2022 to February 2024 were randomly divided into the observation group (n=25 cases) and the control group (n=23 cases). They were all treated with neuroendoscopy-assisted transnasal sphenoidal sinus surgery. The observation group received rTMS therapy on the basis of routine clinical treatment after surgery. The control group was treated in the same way with a false coil with no magnetic pulse emission. Headache, visual recovery, hormone levels and clinical efficacy of the two groups were compared before and after treatment. Results Compared with pre-operation, headache, vision improvement and pituitary hormone level in the two groups increased one month after operation, and the observation group was better than the control group (P < 0.05), and the clinical effect of the observation group was significantly better than that of the control group (P < 0.05). Conclusions Repetitive transcranial magnetic stimulation has a good effect on the improvement of clinical symptoms and the recovery of neuroendocrine function in elderly patients with nonfunctioning pituitary macroadenoma after resection, which is worthy of clinical application. |
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