| 李娜.老年营养风险指数与急性缺血性脑卒中患者认知功能障碍的相关性研究[J].神经损伤功能重建,2024,(5):268-271 |
| 老年营养风险指数与急性缺血性脑卒中患者认知功能障碍的相关性研究 |
| Correlation between Geriatric Nutritional Risk Index and Cognitive Impairment in Patientswith Acute Ischemic Stroke |
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| DOI： |
| 中文关键词: 脑卒中 认知功能 老年营养风险指数 相关性 |
| 英文关键词: stroke cognitive function geriatric nutritional risk index correlation |
| 基金项目: |
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| 中文摘要: |
| 目的：探索老年营养风险指数（geriatric nutritional risk index，GNRI）与急性缺血性脑卒中患者认知功
能障碍（post-stroke cognitive impairment，PSCI）的相关性。方法：选取急性缺血性脑卒中患者368例，收集
临床基线资料，计算入院GNRI水平，评估营养状况。根据GNRI将患者分为GNRI降低组（存在营养风险，
GNRI＜98）和 GNRI 正常组（无营养风险，GNRI≥98）。发病 3 个月后通过简易智能精神状态检查量表
（mini mental state examination，MMSE）评估患者的认知功能，并根据评分将患者分为 PSCI 组和非 PSCI
组。GNRI指数和MMSE量表分数之间的相关性通过Pearson检验进行分析，通过多因素Logistic 回归分析
探索PSCI的影响因素。结果：PSCI的发生率为21.9%。PSCI组和非PSCI组的性别、年龄、教育年限、高血
压、基线NIHSS评分、TOAST分型、GNRI降低率和GNRI评分比较，差异有统计学意义（P＜0.05）。GNRI
降低组和GNRI正常组患者的定向力、语言能力和MMSE总分差异有统计学意义（P＜0.05）。Pearson相关
性分析结果显示GNRI与MMSE总评分呈正相关（r=0.654，P=0.034）。多因素Logistic回归分析显示，GNRI
降低与缺血性脑卒中患者PSCI发生显著相关（OR=2.63，95%CI 1.41～4.90），经过年龄、教育年限、男性、高
血压等因素调整后，GNRI降低依然与卒中后患者PSCI发生显著相关（OR=2.45，95%CI 1.27～4.56）。结
论：急性缺血性脑卒中患者GNRI与MMSE 评分呈正相关，GNRI降低是PSCI发生的独立危险因素。 |
| 英文摘要: |
| To explore the correlation between the geriatric nutritional risk index (GNRI) and
post-stroke cognitive impairment (PSCI) in patients with acute ischemic stroke. Methods: Three hundred and
sixty-eight patients with acute ischemic stroke were enrolled. Clinical baseline data were collected to calculate
the admission GNRI level and assess the nutritional status. Based on their GNRI scores, patients were
categorized into two groups: GNRI reduced group (with nutritional risk, GNRI<98) and GNRI normal group
(without nutritional risk, GNRI≥98). Cognitive function was assessed by the mini-mental state examination
(MMSE) scale at 3 months after stroke onset, and patients were categorized into PSCI and non-PSCI groups
according to their scores. The correlation between GNRI index and MMSE scale scores was analyzed using
Pearson's test. Additionally, factors influencing PSCI were explored by multifactorial Logistic regression
analysis. Results: The incidence of PSCI was 21.9%. There were significant differences in gender, age, years of
education, hypertension, baseline NIHSS scores, TOAST typing, GNRI reduction rate and GNRI scores between
the PSCI and non-PSCI groups (P<0.05). Orientation, verbal ability and MMSE total score between patients in
the GNRI reduction group and the GNRI normal group had a statistically significant difference (P<0.05).
Pearson correlation analysis showed a positive correlation between GNRI and MMSE total score (r=0.654, P=
0.034). Multivariate Logistic regression analysis showed that reduced GNRI was significantly associated with
the occurrence of PSCI in patients with ischemic stroke (OR=2.63, 95% CI 1.41～4.90). After adjusting for age,
years of education, male sex, and hypertension, reduced GNRI remained significantly associated with the
occurrence of PSCI (OR=2.45, 95% CI 1.27～4.56). Conclusion: There is a positive correlation between
GNRI and MMSE scores in patients with acute ischemic stroke, and a decrease in GNRI is an independent risk
factor for the occurrence of PSCI. |
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