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| BDNF亚型改善认知功能障碍研究进展 |
| The Role and Mechanism of BDNF Subtype in Improving Cognitive Impairment |
| 投稿时间：2024-03-15 修订日期：2024-03-15 |
| DOI： |
| 中文关键词: 认知功能障碍 脑源性神经营养因子 突触可塑性 神经递质 |
| 英文关键词: Cognitive impairment Brain-derived neurotrophic factor Synaptic plasticity Neurotransmitter |
| 基金项目: |
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| 中文摘要: |
| 伴随人口衰老，由神经退行性病变导致的认知功能障碍发病率逐年增加。认知功能障碍患者常伴随着神经元病变，其中BDNF对神经元的生长与存活具有重要作用。目前研究主要关注其改善运动功能障碍，而越来越多的证据指出在认知功能方面BDNF也发挥重要调节作用。但现有研究大多局限于观察其表达水平的改变，未能深入的探讨这改变背后的机制。本文对BDNF亚型及其功能的研究进展进行综述，从学习记忆能力、突触结构可塑性以及神经递质等方面剖析其与认知功能障碍的关系。 |
| 英文摘要: |
| With the aging of the population, the incidence of cognitive dysfunction caused by neurodegeneration is increasing year by year. Patients with cognitive dysfunction are often accompanied by neuropathy, in which BDNF plays an important role in the growth and survival of neurons. Current research focuses on its effect of improving motor dysfunction, but there is increasing evidence that BDNF also plays an important regulatory role in cognitive function. Nevertheless, most of the existing researches are limited to observing the change of its expression level, and fail to deeply explore the mechanism behind this change. This review summarizes the research progress of BDNF subtypes and their functions, and analyzes the relationship between BDNF and cognitive dysfunction from the aspects of learning and memory ability, synaptic structural plasticity and neurotransmitters. |
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