| 张亦舒
，李晓宁
，顾雪彤.基于免疫炎性反应探讨肠道菌群在缺血性脑卒中脑损伤中的作用[J].神经损伤功能重建,2024,(3):157-160 |
| 基于免疫炎性反应探讨肠道菌群在缺血性脑卒中脑损伤中的作用 |
| Role of Gut Microbiota in the Brain Injury after Ischemic Stroke Based on ImmuneInflammatory Reaction |
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| DOI： |
| 中文关键词: 肠道菌群 缺血性脑卒中 免疫炎性反应 |
| 英文关键词: gut microbiota ischemic stroke immune inflammatory reaction |
| 基金项目: |
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| 中文摘要: |
| 新近研究发现，缺血性脑卒中的发生打破了肠道生态环境稳态，造成了肠道菌群结构改变及相关衍
生产物失调。这种变化导致了卒中后局部的免疫炎性反应加剧和梗死体积的增大，是影响卒中预后的潜在
危险因素。本文就缺血性脑卒中病程中的炎性反应过程、肠道菌群和相关衍生产物的变化以及脑损伤过程
中由肠道菌群所介导的免疫炎性反应进行综述。 |
| 英文摘要: |
| Ischemic stroke is a type of cerebrovascular disease with a high disability rate. Recent studies have
found that ischemic stroke breaks the stability of the intestinal ecological environment, resulting in alterations in
the composition of gut microbiota and related derivatives. These changes lead to the exacerbation of local
immune inflammatory responses and the increase of infarct volume after stroke, which is a potential risk factor
for stroke prognosis. This review aims to summarize the inflammatory response process, changes in gut
microbiota and related derivatives, as well as the immune inflammatory reactions mediated by gut microbiota
during cerebral infarction. |
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