| 陈华敏,
，瞿娜,.围绝经期和非围绝经期抑郁患者的认知功能与脂代谢的比较[J].神经损伤功能重建,2024,(3):146-150 |
| 围绝经期和非围绝经期抑郁患者的认知功能与脂代谢的比较 |
| Comparison of Cognitive Function and Lipid Profiles in Perimenopausal andNon-Perimenopausal Patients with Depressive Disorder |
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| DOI： |
| 中文关键词: 抑郁障碍 围绝经期 认知功能 脂代谢 |
| 英文关键词: depression perimenopausal period cognitive function lipid profiles |
| 基金项目: |
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| 摘要点击次数: 642 |
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| 中文摘要: |
| 目的：了解围绝经期抑郁患者的认知功能特点以及与脂代谢之间的相互关系。方法：选取女性抑郁
障碍患者66例，其中非围绝经期组45例，围绝经期组21例。采用17项汉密尔顿抑郁量表（Hamilton depression scale，HAMD）和汉密尔顿焦虑量表（Hamilton anxiety scale，HAMA）评估患者抑郁、焦虑情绪，运用蒙
特利尔认知量表（Montreal cognitive assessment，MoCA）评估认知功能，收集血清甘油三酯（TG）、血清总胆
固醇（total cholesterol，TC）、高密度脂蛋白胆固醇（high density lipoprotein-cholesterol，HDL-C）及低密度脂蛋
白胆固醇（low density lipoprotein-cholesterol，LDL-C）的水平，运用酶联免疫吸附法检测血清雌二醇（estradiol，E2）水平。分析2组间认知功能与脂代谢之间的关系，分析影响患者认知功能的因素。结果：女性抑郁
患者中有 40.91%（27/66）认知功能损害，围绝经期组有 80.00%（20/25）认知功能损伤，非围绝经期组有
17.07%（7/41）认知功能损伤，2组有显著性差异（P＜0.001）；围绝经期组的MoCA评分显著低于非围绝经期
组（P=0.000）。与非围绝经期组相比，围绝经期组年龄偏高（P=0.001）、受教育程度偏低（P=0.001）。在视空
间（P＜0.001）、注意（P＜0.001）、语言（P＜0.001）、抽象（P＜0.001）、延迟回忆（P＜0.001）等不同认知域的分
数围绝经期组明显低于非围绝经期组，2组的E2水平、体重指数、发病次数、抑郁、焦虑情绪的评分差异无统
计学意义。围绝经期组的TG、TC、LDL-C均显著高于非围绝经期组（P＜0.01），2组之间HDL-C差异无统
计学意义。TC（r=－0.39，P＜0.01）和LDL（r=－0.41，P＜0.01）与MoCA的得分显著负相关。多元线性回归
分析结果显示LDL与认知功能之间呈负相关（P＜0.05，β=－0.757）。结论：围绝经期抑郁障碍患者的认知
功能较非围绝经期抑郁障碍患者明显下降，TC和LDL可能是围绝经期女性抑郁障碍患者认知功能损伤的
危险因素。 |
| 英文摘要: |
| To investigate characteristics of cognitive function in perimenopausal depressive
disorder patients and their interrelationship with lipid profiles. Methods: A total of 66 female patients with
depressive disorder were enrolled, including 45 cases in the non-menopausal group and 21 cases in the
perimenopausal group. The 17-item Hamilton Depression Scale and Hamilton Anxiety Scale were used to assess
patients' depression and anxiety, respectively, and the Montreal Cognitive Assessment (MoCA) was used to
evaluate cognitive function. The triglyceride (TG), serum total cholesterol (TC), high-density lipoprotein (HDL),
and low-density lipoprotein (LDL) levels were collected from clinical records. An enzyme-linked
immunosorbent assay was used to detect estradiol (E2) level. Independent sample t test were used to analyze the
relationships between cognitive function and lipid profiles between the two groups. Correlation and multiple
linear regression methods were used to analyze the factors affecting the cognitive function of patients. Results:
Among female patients with depressive disorder, 40.91% (27/66) had cognitive impairment, with 80.00% (20/
25) in the perimenopausal group and 17.07% (7/41) in the non-perimenopausal group. There was a statistically
significant difference in cognitive function impairment between the two groups (P<0.001). The MoCA score in
the perimenopausal group was significantly lower than that in the non-perimenopausal group (P=0.000).
Compared with the non-perimenopausal group, the perimenopausal group was older (P=0.001) and less educated
(P= 0.001). The visual space (P<0.001), attention (P<0.001), language (P<0.001), abstraction (P<0.001), and
delayed recall (P<0.001) scores in the non-perimenopausal group were significantly higher than those in the
perimenopausal group. There was no statistically significant difference in the E2 level, body mass index, number
of episodes, depression, or anxiety score between the two groups. TC (P=0.002), TG (P=0.008), and LDL (P=
0.007) levels in the perimenopausal group were significantly higher than those in the non-perimenopausal group,
but there was no statistically significant difference in HDL levels. TC (r=－0.39, P<0.01) and LDL (r=－0.41, P<0.01) were significantly
negatively associated with MoCA scores. Multiple linear regression analysis revealed a negative correlation between LDL and cognitive
function (P<0.05, β =－ 0.757). Conclusion: Cognitive function was significantly lower in perimenopausal patients with depressive
disorder compared to non-perimenopausal patients. TC and LDL may be risk factors for cognitive impairment in perimenopausal women
with depressive disorders. |
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