| 张洪铭
，冯丽娜,
，孙保亮,,.阿尔茨海默病与铁死亡相关性的研究进展[J].神经损伤功能重建,2024,(2):105-108 |
| 阿尔茨海默病与铁死亡相关性的研究进展 |
| Research Progress on the Relevance between Alzheimer’s Disease and Ferroptosis |
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| DOI： |
| 中文关键词: 阿尔茨海默病 铁死亡 铁代谢紊乱 脂质过氧化 综述 |
| 英文关键词: Alzheimer’s disease ferroptosis iron metabolism disorder lipid peroxidation review |
| 基金项目:山东第一医科大学
（山东省医学科学
院）学术提升计划
（神经系统疾病防
治新靶点及干预，
No. 2019QL016） |
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| 摘要点击次数: 314 |
| 全文下载次数: 297 |
| 中文摘要: |
| 阿尔茨海默病（Alzheimer’s disease，AD）是最常见的痴呆类型，是以进行性认知功能障碍为主要表现
的神经系统退行性病变。调节性细胞死亡是基因决定的细胞主动有序的死亡，普遍存在于在生命体发育过
程中，对调节生命稳态至关重要。随着调节性细胞死亡在AD的广泛研究，越来越多的证据揭示铁死亡与
AD的发生、发展以及转归密切相关。本文将对铁死亡的分子机制及其在AD中的调控作用进行综述，为
AD的发病机制和治疗探索潜在治疗靶点。 |
| 英文摘要: |
| Alzheimer’s disease (AD) is the most common type of dementia, characterized by progressive
cognitive dysfunction as a primary manifestation of neurodegenerative changes. Regulated cell death, an active
and orderly form of cell demise determined by genetic factors, is ubiquitous during the development of living
organisms and is crucial for maintaining life homeostasis. With extensive research on regulated cell death in AD,
increasing evidence reveals that ferroptosis is closely related to the onset, progression, and outcome of AD. This
article will review the molecular mechanisms of ferroptosis and its regulatory role in AD, providing insights into
potential therapeutic targets for exploring the pathogenesis and treatment of AD. |
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