高小姗
,雒扬
,姚利和
,谷有全.脑梗死治疗中的新视角:热休克蛋白的作用[J].神经损伤功能重建,2024,(2):101-104 |
脑梗死治疗中的新视角:热休克蛋白的作用 |
New Perspectives in Cerebral Infarction Therapy: The Role of Heat Shock Proteins |
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DOI: |
中文关键词: 脑梗死 缺血性脑损伤 热休克蛋白 治疗 |
英文关键词: cerebral infarction ischemic brain injury heat shock proteins treatment |
基金项目:国家自然科学基金
项目(维生素 A 调
控NaCl-SGK1-Fox
O1/IL-23R 信 号 通
路抵抗高盐介导的
tTreg/Th17 免 疫 失
衡治疗高盐饮食的
EAE小鼠,No. 819
60293);甘肃省自
然科学基金(替格
瑞 洛 在 CYP2C19
功能缺失等位基因
携带者神经介入治
疗中有效性及安全
性 的 研 究 观 察 ,
No. 22JR5RA941) |
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中文摘要: |
脑梗死是脑组织血液供应障碍引发的一类疾病,会导致患者出现不同程度的神经功能缺损、认知功
能障碍等,降低患者的生活质量。热休克蛋白(heat shock proteins,HSPs)可作为缺血相关的应激蛋白在脑
组织缺血后被诱导激活,在脑损伤中起到重要作用。近年来,越来越多的研究指出HSPs与脑梗死有着密切
的关联,靶向特定的HSP可缓解缺血性脑损伤,极大改善预后。因此,本文对与脑梗死相关的HSPs的最新
文献进行概述,为后续靶向HSPs相关药物的研发及临床转化提供理论依据,为脑梗死提供新的治疗思路。 |
英文摘要: |
Cerebral infarction is a type of disease caused by blood supply disorders in brain tissue, leading to
varying degrees of neurological deficits and cognitive dysfunction in patients, reducing their quality of life. Heat
shock proteins (HSPs) can be induced and activated after cerebral ischemia as stress proteins related to ischemia,
playing an important role in brain damage. In recent years, more and more studies have pointed out that HSPs
are closely associated with cerebral infarction, and targeting specific HSPs can alleviate ischemic brain damage
and greatly improve prognosis. Therefore, this review article provides an overview of the latest literature on the
relevant HSPs involved in cerebral infarction, providing a theoretical basis for the subsequent development and
clinical transformation of drugs targeting HSPs, offering new treatment ideas for cerebral infarction. |
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