文章摘要
吴艳萍，陈真真，李昌俊，经屏.老年脑卒中患者血清25-羟维生素D3浓度与抑郁状态的相关性研究[J].神经损伤功能重建,2024,(2):86-89
老年脑卒中患者血清25-羟维生素D3浓度与抑郁状态的相关性研究
Study on the Correlation between Serum 25-Hydroxyvitamin D3 Concentration andDepressive State in Elderly Patients with Stroke
  
DOI：
中文关键词: 老年人  25-羟维生素D3  脑卒中  抑郁
英文关键词: the olderly  25-hydroxyvitamin D3  stroke  depression
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作者单位
吴艳萍，陈真真，李昌俊，经屏 华中科技大学同济 医学院附属武汉市 中心医院神经内科 
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中文摘要:
      目的：本研究旨在探讨65岁及以上的脑卒中患者血清25-羟维生素D3[25-hydroxyvitamin D3，25(OH) D3] 浓度与抑郁状态之间的相关性。方法：收集美国国家健康与营养调查（National Health and Nutrition Examination Survey, NHANES）数据中年龄≥65 岁的老年脑卒中患者的相关数据，根据患者健康问卷-9（Patient Health Questionnaire 9-item，PHQ-9）测评结果评估抑郁状态，据此分为非抑郁组和抑郁组；比较2组 患者各项临床数据差异，采用多因素 Logistic 回归模型评估血清 25(OH)D3浓度与抑郁状态之间的相关 性。结果：纳入年龄≥65岁的脑卒中患者600例，其中76例（12.67%）纳入抑郁组。抑郁组患者的年龄和血 清25(OH)D3浓度低于非抑郁组（均P＜0.05），婚姻状况为结婚或同居的比例高于非抑郁组（P＜0.05）；多因 素Logistic回归分析结果显示，血清25(OH)D3浓度升高与抑郁症状发生风险呈负相关（OR=0.917, 95%CI 0.844～0.997, P=0.042）。结论：老年脑卒中患者血清25(OH)D3浓度升高与抑郁状态的发生风险呈负相关， 建议对该人群常规筛查血清25(OH)D3。
英文摘要:
      This study aims to investigate the correlation between serum 25-hydroxyvitamin D3 [25 (OH)D3] concentration and depressive state in stroke patients aged 65 years and above. Methods: Relevant data of elderly stroke patients (≥65 years old) were collected from the National Health and Nutrition Examination Survey (NHANES), and depressive state was assessed according to the results of the Patient Health Questionnaire 9-item (PHQ-9). Patients were divided into non-depressed and depressed groups based on these assessments. Differences in clinical data between the two groups were compared, and a multivariate Logistic regression model was used to evaluate the correlation between serum 25(OH)D3 concentration and depressive state. Results: A total of 600 stroke patients aged ≥65 years were included, of which 76 cases (12.67%) were included in the depression group. The age and serum 25(OH)D3 concentration of patients in the depression group were lower than those in the non-depression group (both P<0.05), and the proportion of marital status being married or cohabiting was higher than that in the non-depression group (P<0.05). Multivariate Logistic regression analysis showed that increased serum 25(OH)D3 concentration was negatively correlated with the risk of depressive symptoms (OR=0.917, 95%CI 0.844-0.997, P=0.042). Conclusion: The increase in serum 25(OH)D3 concentration is negatively correlated with the risk of depressive state in elderly stroke patients, suggesting that routine screening of serum 25(OH)D3 should be recommended for this population.
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