| parkinson's disease (PD) is the second largest neurodegenerative disease in the world. Its pathological factors are complex and diverse, and neuroinflammation caused by long-term sustained stimulation is one of the main pathological factors. In the process of PD pathogenesis, alpha-synuclein misfolding and mitochondrial DNA are released by the mitochondria injury induced microglia activation, damage the brain inflammation factor equilibrium state, lead to neuronal damage, so by microglia mediated inflammatory response is a key link of PD pathogenesis process, and it is one of the most promising therapeutic targets. Therefore, this article summarizes the source, type, function and possible mechanism of microglia in the pathogenesis of PD, as well as PD therapy targeting microglia, in order to have a deeper understanding of the role of microglia in PD and potential treatment strategies. |