| 叶启航
，李艺,
，张云梦
，叶军明,.纳米递送系统在脊髓损伤中的研究进展[J].神经损伤功能重建,2024,(1):45-50 |
| 纳米递送系统在脊髓损伤中的研究进展 |
| Research Progress of Nano Delivery Systems in Spinal Cord Injury |
| |
| DOI： |
| 中文关键词: 脊髓损伤 纳米粒子 靶向治疗 纳米递送 |
| 英文关键词: spinal cord injury nanoparticles targeted therapy nano delivery |
| 基金项目:国家科学自然基金
（原位注射bFGF-E
CM-HP 温 敏 型 水
凝胶治疗脊髓损伤
的作用和作用机制，
No. 81760230）；江
西省科学自然基金
（近 红 外 光 响 应
PDA-HP 水凝胶改
善线粒体功能的脊
髓损伤光热治疗研
究，No. 20224BAB
216047） |
|
| 摘要点击次数: 1082 |
| 全文下载次数: 1463 |
| 中文摘要: |
| 脊髓损伤（spinal cord injury，SCI）是一种严重的神经系统疾病，其主要的临床治疗包括急救处理、手
术、药物治疗和康复治疗。常规的药物治疗存在难以穿越血脊髓屏障（blood-spinal cord barrier，BSCB）、不
能靶向受损的神经组织的问题。纳米递送系统具有良好的可控释放特性和靶向脊髓组织的能力，可以克
服常规给药方式的不足，通过精细化设计组装和外表修饰赋予纳米递送系统出众的治疗效果。本文综述
了在SCI中纳米粒子用于药物递送的研究进展，并着重介绍在SCI药物递送系统中的靶向策略及具有运用
前景的纳米粒子及其各自特性与局限性，以及将纳米递送技术应用于临床SCI修复领域所需克服的努力与
障碍。 |
| 英文摘要: |
| Spinal cord injury (SCI) is a severe neurological condition. The primary clinical interventions
include emergency treatment, surgical procedures, drug therapy, and rehabilitation programs. However,
Conventional drug therapy is difficult to cross the Blood-spinal cord barrier (BSCB) and cannot target damaged
nerve tissue. In contrast, nano-drug delivery systems offer controlled release properties and can precisely target
spinal cord tissue, thereby overcoming the limitations of traditional drug therapies. Through exquisite design,
assembly and external modification, the nanomedical drug delivery system has outstanding therapeutic effects.
This paper reviews the current research status of Nanoparticles for drug delivery in SCI. Furthermore, this article
emphasizes the targeting strategies utilized in drug delivery systems for spinal cord injury, as well as the
potential of nanoparticles and their respective characteristics and limitations. Finally, the efforts and obstacles to
be overcome in the application of nanoparticle drug delivery technology in the field of clinical SCI repair are
discussed. |
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