|
| Toll样受体 2/3/4与新生儿脑损伤的研究进展 |
| The Role of Toll-like receptor 2/3/4 in Neonatal brain injury |
| 投稿时间：2024-01-08 修订日期：2024-01-08 |
| DOI： |
| 中文关键词: Toll样受体 TLR2 TLR3 TLR4 新生儿脑损伤 |
| 英文关键词: Toll like receptors TLR2 TLR3 TLR4 Neonatal brain injury |
| 基金项目:甘肃省教育厅科技创新基金项目（2022B-024） |
|
| 摘要点击次数: 459 |
| 全文下载次数: 0 |
| 中文摘要: |
| 新生儿脑损伤的发生发展机制目前尚未完全阐明，但炎症反应已经被公认在其中发挥重要作用。作为机体先天性免疫反应的重要受体，Toll样受体信号通路与炎症的激活密切相关。Toll样受体家族成员TLR2、TLR3和TLR4可以通过多种机制促进脑损伤后炎症因子和趋化因子的表达，从而影响新生儿脑损伤的进程及预后。笔者现围绕TLR2、TLR3和TLR4在新生儿脑损伤中的研究进展进行综述，以期为该病的机制理解提供帮助，也为靶向Toll样受体治疗新生儿脑损伤的研究提供一些思路借鉴。 |
| 英文摘要: |
| The mechanism of the occurrence and development of neonatal brain injury remains largely unknown, but the inflammatory damage has been recognized to play an important role. As an important receptor for the innate immune response, the Toll-like receptor-related signaling pathway is closely related to the activation of inflammation. Toll-like receptor family members TLR2, TLR3 and TLR4 could promote the expression of inflammatory cytokines through various mechanisms, thereby affecting the progression and prognosis of neonatal brain injury. The authors now review the research progress of TLR 2, TLR 3 and TLR 4 in neonatal brain injury, in order to provide help for the mechanistic understanding of the disease, and also provide some ideas and reference for the drug development of targeted Toll-like receptors that can be used in the treatment of neonatal brain injury. |
|
View Fulltext
查看/发表评论 下载PDF阅读器 |
| 关闭 |