|
| 蛋白质乳酸化修饰及其在神经系统疾病中的研究进展 |
| Lactylation Modification and Its Research Progress in Neurological Disorders |
| 投稿时间：2024-01-07 修订日期：2024-01-07 |
| DOI： |
| 中文关键词: 翻译后修饰、乳酸化修饰、神经系统性疾病 |
| 英文关键词: PTMs Lactylation Neurological diseases |
| 基金项目:国家自然科学基金 |
|
| 摘要点击次数: 2318 |
| 全文下载次数: 0 |
| 中文摘要: |
| 乳酸化修饰是新近发现的一种作用于组蛋白和非组蛋白上的翻译后修饰类型。自2019年Zhang等首次在核心组蛋白上发现乳酸化修饰位点以来，众多研究者已将目光聚焦于乳酸化修饰与神经系统疾病之间的关系，并积极探索通过调控乳酸化修饰以期改善中枢神经系统疾病患者的预后。本文综述了乳酸化修饰与多种神经系统疾病（如阿尔茨海默病、脑缺血再灌注损伤、新生儿缺血缺氧性脑病）之间的关联及调控机制，这些研究不仅丰富了我们对乳酸化修饰的认识，还为神经系统性疾病的治疗提供了新思路。拟通过深入了解乳酸化修饰在不同神经疾病中的作用机制以期为未来研究提供有价值的参考依据。 |
| 英文摘要: |
| Lactylation is a recently discovered post-translational modification that occurs on both histone and non-histone proteins. Since the identification of lactylation modification sites on core histones by Zhang et al. in 2019, numerous researchers have shifted their focus towards exploring the relationship between lactylation and neurological disorders, aiming to regulate lactylation to improve the prognosis of central nervous system diseases. This article provides an overview of the associations and regulatory mechanisms between lactylation and various neurological disorders, such as Alzheimer's disease, cerebral ischemia reperfusion injury and Hypoxic-ischemic encephalopathy. These studies not only enrich our understanding of lactylation, but also offer a new perspective for the treatment of neurological disorders. By gaining a deeper insight into the mechanistic roles of lactylation in different neurological diseases, valuable references are provided for future research endeavors. |
|
View Fulltext
查看/发表评论 下载PDF阅读器 |
| 关闭 |