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| CD22在神经退行性疾病中的作用 |
| Role of CD22 in neurodegenerative diseases |
| 投稿时间：2023-12-31 修订日期：2023-12-31 |
| DOI： |
| 中文关键词: CD22 小胶质细胞 吞噬作用 神经退行性疾病 |
| 英文关键词: CD22 Microglia Phagocytosis Neurodegenerative diseases |
| 基金项目:组蛋白乙酰化-miRNA（miR-671、miR-483-5p）环路调控海马神经元树突棘重塑在孕晚期母体接受丙泊酚麻醉手术致子代大鼠学习记忆损害中的作用 |
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| 中文摘要: |
| 小胶质细胞是非常重要的免疫细胞，它广泛分布于中枢神经系统，能持续地观察和感知周围微环境，一方面通过释放各种细胞炎症因子平衡机体的免疫反应，另一方面通过吞噬突触和细胞调节神经网络功能。小胶质细胞的功能失调是参与神经退行性疾病发生或加剧的主要机制，因此恢复小胶质细胞的功能可能是一种潜在的治疗模式。CD22是唾液酸结合免疫球蛋白型凝集素家族的重要成员，通常表达于B细胞表面，起到免疫抑制作用。近期， CD22被证明能通过小胶质细胞改善老年小鼠的认知功能，这一发现有望使CD22成为治疗神经退行性疾病的新靶点。 |
| 英文摘要: |
| Microglia are very important immune cells, which are widely distributed in the central nervous system, and can continuously observe and perceive the surrounding microenvironment, on the one hand, by releasing various cellular inflammatory factors to balance the body's immune response, and on the other hand, by phagocytosis synapses and cells to regulate neural network functions. Microglial dysfunction is a major mechanism involved in the onset or exacerbation of neurodegenerative diseases, so restoring microglial function may be a potential therapeutic modality. CD22 is an important member of the sialic acid-binding immunoglobulin-type lectin family, which is usually expressed on the surface of B cells and plays an immunosuppressive role. Recently, CD22 has been shown to improve cognitive function in elderly mice through microglia, which is expected to make CD22 a new target for the treatment of neurodegenerative diseases. |
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