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| 组织金属蛋白酶抑制剂-1在中枢神经系统疾病中的研究进展 |
| Recent Advances in Research on Organizing Metalloproteinase Inhibitor-1 in Central Nervous System Diseases: A Review |
| 投稿时间：2023-11-30 修订日期：2023-11-30 |
| DOI： |
| 中文关键词: 中枢神经系统疾病 组织金属蛋白酶抑制剂-1 组织金属蛋白酶-9 血脑屏障 细胞外基质 预后 |
| 英文关键词: central nervous system disorders tissue metalloproteinase inhibitor-1 tissue metalloproteinase-9 blood-brain barrier extracellular matrix prognosis |
| 基金项目:国家自然科学基金资助项目（82205065,82272598）;广东省基础与应用基础研究基金（2020A1515111062，2020A1515011203）;深圳市科学技术创新委员会（JCYJ20220530150407015，JCYJ20210324135804012）;深圳市第二人民医院临床研究基金（20213357022）。 |
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| 中文摘要: |
| 摘要：中枢神经系统（central nervous system，CNS）疾病以神经血管单元功能障碍及病变为主要特征，是引起失能、半失能的主要原因之一，其发病率高病程长。组织金属蛋白酶抑制剂-1（tissue inhibitors of metalloproteinase 1, TIMP-1）是基质金属蛋白酶-9（matrix metalloproteinases 9，MMP-9）的天然抑制剂，也是维持细胞外基质结构稳态的关键蛋白之一，对神经血管单元的损伤修复至关重要。最新研究表明，TIMP-1具有不依赖于MMPs途径的功能，通过与细胞表面受体结合发挥生物学功能成为一种新兴多功能细胞因子。TIMP-1水平变化与CNS疾病的发生和预后直接相关，以TIMP-1为靶点的调控可促进神经血管单元功能的恢复。本文就近年来TIMP-1在CNS疾病中的研究进展进行综述，以期全面探讨TIMP-1在脑血管损伤、癫痫以及神经退行性疾病发生发展中的作用及机制。促进TIMP-1在CNS疾病中的转化应用研究。 |
| 英文摘要: |
| Abstract: Central nervous system (CNS) disorders, characterized by dysfunction and pathology in neurovascular units, represent a leading cause of disability, with high incidence and protracted courses. Tissue inhibitors of metalloproteinase 1 (TIMP-1) serve as natural inhibitors of matrix metalloproteinase 9 (MMP-9) and are critical for maintaining extracellular matrix homeostasis. Recent research has unveiled novel, MMP-independent functions of TIMP-1, as it acts as a multifaceted cell factor by binding to cell surface receptors. Fluctuations in TIMP-1 levels directly correlate with the occurrence and prognosis of CNS diseases, making TIMP-1 a promising target for promoting neurovascular unit repair. In this review, we comprehensively examine the recent advances in TIMP-1 research within the context of CNS diseases, exploring its roles and mechanisms in brain vascular injury, epilepsy, and neurodegenerative disorders. We aim to foster translational studies harnessing TIMP-1 for applications in CNS disease management. |
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