| 江娜，许元，冯林玉，谢敏杰.中性粒细胞在缺血性脑卒中的作用研究进展[J].神经损伤功能重建,2023,(11):651-655 |
| 中性粒细胞在缺血性脑卒中的作用研究进展 |
| Role of Neutrophils in Ischemic Stroke |
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| DOI： |
| 中文关键词: 缺血性脑卒中 中性粒细胞 中性粒细胞外陷阱 |
| 英文关键词: ischemic stroke neutrophils neutrophil extracellular traps |
| 基金项目:国家自然科学基
金（调节性 T 细
胞在慢性低灌注
脑白质缺血后结
构与功能重塑中
的作用及其机制
研究，No. 819741
80）及湖北省医
学青年拔尖人才
项目（缺血性白
质损伤神经保护
干预的胶质细胞
新标靶研究，No.
2021SCZ052） |
|
| 摘要点击次数: 544 |
| 全文下载次数: 901 |
| 中文摘要: |
| 缺血性脑卒中是一种急性中枢神经系统疾病，发病率、致死率、致残率居高不下，给患者家庭和社会带
来了极大负担。缺血性脑卒中病理机制复杂，治疗手段有限，亟需进一步探索病理机制及新的治疗靶点。既
往中性粒细胞在缺血性脑卒中的作用长期被忽视，但近十年的研究提示中性粒细胞活跃参与了缺血性脑卒
中后神经损伤与修复过程。同时，中性粒细胞胞外陷阱（neutrophil extracellular traps，NETs）作为中性粒细胞
的一种新的调控机制，在缺血性脑卒中后急性炎症、血栓形成、血管损害等病理过程中发挥重要作用，可能是
促进缺血性脑卒中后新生血管和功能恢复的关键。本文重点评述了中性粒细胞特别是NETs在缺血性脑卒
中神经损伤与修复中的作用以及靶向中性粒细胞和NETs治疗的相关进展。 |
| 英文摘要: |
| Ischemic stroke is an acute central nervous system disease with high morbidity, mortality, and disability
rates, imposing a significant burden on patients’families and society. Pathological changes in ischemic stroke are
complex, and the available treatment options are limited. Therefore, it is urgent to further explore the pathological
mechanisms and identify new therapeutic targets. The role of neutrophils in ischemic stroke has long been
neglected. However, research in the past decade has suggested that neutrophils are actively involved in nerve
injury and repair after ischemic stroke. In addition, neutrophil extracellular traps (NETs), a new regulatory
mechanism of neutrophils, play an important role in acute inflammation, thrombosis, vascular damage, and other
pathological processes after ischemic stroke, potentially being a key target in promoting neovascularization and
functional recovery post-ischemic stroke. This review focuses on the role of neutrophils, especially NETs, in nerve
injury and repair after ischemic stroke, along with advances in treatments targeting neutrophils and NETs. |
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