| 【 Abstract 】 Objective To observe the clinical features, blood-brain barrier function and short-term prognosis of NMOSD patients with enlarged perivascular space (EPVS), and to explore the clinical value of EPVS in recognizing severe neurological deficits.Methods Clinical datas of patients with acute NMOSD were admitted to the First Affiliated Hospital of Zhengzhou University from December 2019 to February 2023 were retrospectively collected. According to the number of EPVS,the patients were divided into mild group (58 cases) and severe group (21 cases). The general clinical data，laboratory examination and focal distribution characteristics of the two groups were compared．Spearman rank correlation was used to evaluate the correlation between EPVS and albumin quotient and EDSS score in NMOSD patients. To explore the clinical value of EPVS in recognizing severe neurological deficits in NMOSD patients based on ROC curve．Results Age,cerebrospinal fluid albumin and immunoglobulin,albumin quotient,immunoglobulin quotient，protein positive rate,EDSS score at admission，discharge and 3 months after discharge of NMOSD patients in moderate and severe EPVS group were higher than those in mild EPVS group,with statistical significance (p<0.05)．There was no significant difference in gender,course of disease，first symptom,positive rate of autoimmune antibody and AQP4 antibody,serum albumin and immunoglobulin,white blood cell count in cerebrospinal fluid,percentage of lymphocytes and monocytes，and focal distribution between the two groups (p>0.05)．Spearman rank correlation results showed that EPVS were positively correlated withalbumin quotient (r=0.284,p=0.011)，EDSS score at admission(rs =0.510, p<0.001),discharge(rs=0.526,p<0.001)and 3 months after discharge(rs =0.544,p<0.01).The area under ROC curve (AUC) for the identification of severe neurological impairment by EPVS number was 0.838 (95%CI:0.735-0.942, p<0.001).Conclusion There was no correlation between EPVS and lesion distribution in NMOSD patients,but EPVS may be related to blood-brain barrierfunction and short-term poor prognosis in NMOSD patients, which should be paid attention to. |