| 胡博玄，刘子华，赵小云，刘红朝.创伤性脑损伤中“脑-肠轴”调节机制的研究进展[J].神经损伤功能重建,2023,(10):601-603 |
| 创伤性脑损伤中“脑-肠轴”调节机制的研究进展 |
| Progress in Research on the“Brain-Gut Axis”Regulation Mechanism in Traumatic Brain Injury |
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| DOI： |
| 中文关键词: 脑-肠轴 创伤性颅脑损伤 肠道微生物群 |
| 英文关键词: brain-gut axis traumatic brain injury gut microbiota |
| 基金项目:湖北省卫生厅科
技攻关项目（No.
jx4b42） |
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| 中文摘要: |
| 创伤性脑损伤（TBI）具有高发病率、高致残率、高致死率的特点。其治疗除处理颅脑损伤外，还需要关
注损伤后出现的一系列继发性损伤和并发症。肠道微生物群和中枢神经系统之间的双向信号通路，称为脑-
肠轴。研究证实，在TBI的继发性损伤中，存在具有双向调节作用的脑-肠轴，影响着TBI的进展与预后，但目
前关于脑-肠轴在TBI后的功能和机制尚未完全明确。本综述将对TBI后脑-肠轴的双向调节机理研究进展进
行总结分析。 |
| 英文摘要: |
| Traumatic brain injury (TBI) is characterized by high morbidity, high disability rate, and high mortality.
In addition to treating intracranial injuries, treatment of TBI also requires attention to a series of secondary injuries
and complications that occur after injury. The bidirectional signaling pathway between the intestinal microbiome
and the central nervous system is known as the brain-gut axis. Research has confirmed that in the secondary injury
of TBI, there exists a brain-gut axis with bidirectional regulation affecting the progression and prognosis of TBI,
but the functional and mechanistic aspects of the brain-gut axis after TBI have not yet been fully clarified. This review will summarize and analyze the progress in research on the bidirectional regulation mechanism of the
brain-gut axis after TBI. |
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