文章摘要
胡博玄,刘子华,赵小云,刘红朝.创伤性脑损伤中“脑-肠轴”调节机制的研究进展[J].神经损伤功能重建,2023,(10):601-603
创伤性脑损伤中“脑-肠轴”调节机制的研究进展
Progress in Research on the“Brain-Gut Axis”Regulation Mechanism in Traumatic Brain Injury
  
DOI:
中文关键词: 脑-肠轴  创伤性颅脑损伤  肠道微生物群
英文关键词: brain-gut axis  traumatic brain injury  gut microbiota
基金项目:湖北省卫生厅科 技攻关项目(No. jx4b42)
作者单位
胡博玄,刘子华,赵小云,刘红朝 湖北中医药大学 附 属 新 华 医 院/ 湖北省中西医结 合 医 院 神 经 外 科 
摘要点击次数: 666
全文下载次数: 782
中文摘要:
      创伤性脑损伤(TBI)具有高发病率、高致残率、高致死率的特点。其治疗除处理颅脑损伤外,还需要关 注损伤后出现的一系列继发性损伤和并发症。肠道微生物群和中枢神经系统之间的双向信号通路,称为脑- 肠轴。研究证实,在TBI的继发性损伤中,存在具有双向调节作用的脑-肠轴,影响着TBI的进展与预后,但目 前关于脑-肠轴在TBI后的功能和机制尚未完全明确。本综述将对TBI后脑-肠轴的双向调节机理研究进展进 行总结分析。
英文摘要:
      Traumatic brain injury (TBI) is characterized by high morbidity, high disability rate, and high mortality. In addition to treating intracranial injuries, treatment of TBI also requires attention to a series of secondary injuries and complications that occur after injury. The bidirectional signaling pathway between the intestinal microbiome and the central nervous system is known as the brain-gut axis. Research has confirmed that in the secondary injury of TBI, there exists a brain-gut axis with bidirectional regulation affecting the progression and prognosis of TBI, but the functional and mechanistic aspects of the brain-gut axis after TBI have not yet been fully clarified. This review will summarize and analyze the progress in research on the bidirectional regulation mechanism of the brain-gut axis after TBI.
查看全文   查看/发表评论  下载PDF阅读器
关闭