文章摘要
仲文庆,俞兴,杨永栋.脊髓室管膜区内源性神经干细胞在脊髓损伤修复中的潜在作用机制研究[J].神经损伤功能重建,2023,(10):589-592
脊髓室管膜区内源性神经干细胞在脊髓损伤修复中的潜在作用机制研究
The Potential Role of Endogenous Neural Stem Cells in Ependymal Region of Spinal Cord inthe Repair of Spinal Cord Injury
  
DOI:
中文关键词: 脊髓损伤  内源性神经干细胞  室管膜细胞  增殖  分化
英文关键词: spinal cord injury  endogenous neural stem cells  ependymal cells  proliferation  differentiation
基金项目:国家自然科学基金 (No. 81973882)
作者单位
仲文庆,俞兴,杨永栋 北京中医药大学东 直门医院 
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中文摘要:
      脊髓损伤是中枢神经系统的严重损伤,目前尚缺乏有效的治疗。近年来发现脊髓室管膜区存在内源 性神经干细胞(ENSCs)具有促进脊髓损伤修复的潜力。脊髓损伤及微环境改变等可使脊髓室管膜区的 ENSCs激活、增殖、分化,进一步修复受损的神经结构。虽然脊髓室管膜区ENSCs在脊髓损伤修复中具有 积极作用,但其机制尚无定论。本文对脊髓室管膜区ENSCs在脊髓损伤修复中潜在作用机制进行综述,为 基础和临床领域全面认识脊髓室管膜区ENSCs提供参考。
英文摘要:
      Spinal cord injury is a serious injury of the central nervous system, and there is currently a lack of effective treatment. In recent years, it has been found that endogenous neural stem cells (ENSCs) in ependymal region of spinal cord have the potential to promote the repair of spinal cord injury. Spinal cord injury and microenvironment changes can promote the activation, proliferation, and differentiation of ENSCs in the ependymal region of the spinal cord, which helps to repair damaged neural structures. Although ENSCs play a positive role in the repair of spinal cord injury, the mechanism remains inconclusive. This article reviews the potential mechanism of spinal cord ependymal region ENSCs in the repair of spinal cord injury, providing more data to know the function of ENSCs in ependymal region of spinal cord from both basic and clinical perspective.
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