| 鲁菁
，屈媛媛
，邵玉莹
，郭述豪
，冯楚文,
，孙维伯
，李彬彬
，孙冬玮
，杨添淞,,.创伤性颅脑损伤动物模型研究概况[J].神经损伤功能重建,2023,(9):534-538 |
| 创伤性颅脑损伤动物模型研究概况 |
| A General Review of Animal Models of Traumatic Brain Injury |
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| DOI： |
| 中文关键词: 创伤性颅脑损伤 动物模型 综述 |
| 英文关键词: traumatic brain injury animal models review |
| 基金项目:深圳市基础研究专
项（No. 202103190
94926010） |
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| 摘要点击次数: 633 |
| 全文下载次数: 730 |
| 中文摘要: |
| 创伤性颅脑损伤（TBI）是世界上青年人致残、致死的主要原因，动物模型作为TBI损伤机制的研究载体，
对研究TBI发生发展和具体损伤机制具有重要作用。由于TBI病理机制复杂，目前关于TBI动物模型的建
造方案较多，大多从损伤病因及损伤性质进行区别，但尚无统一的TBI模型制备标准，且仍处于不断开发、补充
和完善中。本文总结了国内外TBI模型常用的实验动物，并根据局灶性损伤、弥漫性损伤和混合性损伤三种
TBI不同损伤性质对常见TBI的造模方法进行综述，以期为TBI的基础研究和临床治疗提供思路和帮助。 |
| 英文摘要: |
| Traumatic craniocerebral injury (TBI) is the main cause of disability and death among young
individuals worldwide. Animal models are important tools for studying the underlying mechanism of TBI injury
and play an important role in studying the occurrence and development of TBI and its specific injury process.
Due to the complicated pathological mechanisms of TBI, there are currently various protocols for establishing
TBI animal models, mostly based on the cause and nature of injury. However, there is no unified standard for the
preparation of TBI model, and the field is still evolving, with ongoing development, supplementation and
improvement. This paper summarizes the experimental animals commonly used for TBI worldwide, and,
reviews the commonly used modeling methods of TBI based on the different injury characteristics: focal injury,
diffuse injury and mixed injury. This review will provide insights and assistance for basic research and clinical
treatment of TBI. |
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