| 李煜，吴超然，张雨濛，廖红.GABAB受体在中枢神经系统疾病中作用的研究进展[J].神经损伤功能重建,2023,(9):526-529 |
| GABAB受体在中枢神经系统疾病中作用的研究进展 |
| Research Advancements of GABAB Receptors in Diseases of Central Nervous System |
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| DOI： |
| 中文关键词: γ-氨基丁酸 GABAB受体 中枢神经系统疾病 药物研发 |
| 英文关键词: γ-aminobutyric acid GABAB receptor central nervous system diseases pharmaceutical
development |
| 基金项目: |
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| 中文摘要: |
| 中枢神经系统（central nervous system，CNS）疾病由于病因和发病机制的复杂性，目前仍缺乏有效的
治疗手段。GABAB受体广泛分布于神经元和胶质细胞中，在调节神经递质释放和神经元兴奋性中发挥重
要作用。现已证明GABAB受体参与多种CNS疾病的发生发展，包括癫痫、抑郁、脑卒中、阿尔茨海默病及
自身免疫性脑炎等疾病。因此，明确GABAB受体在CNS疾病中的病理角色，对GABAB受体相关药物的开
发及临床应用至关重要。本文从GABAB受体结构和功能出发，综述其参与各类CNS疾病的具体机制。 |
| 英文摘要: |
| Objective Due to the complexity of the etiology and pathogenesis, there is still no effective
therapeutic strategies for diseases of the central nervous system (CNS). GABAB receptors are widely distributed
in neurons and glial cells, and play important roles in the regulation of neurotransmitter release and neuronal
excitability. It has been proven that GABAB receptors are involved in the development of a variety of CNS
diseases, including epilepsy, depression, stroke, Alzheimer's disease, and autoimmune encephalitis. Therefore,
clarifying the roles of GABAB receptors in the pathology of CNS diseases is essential for the development and
clinical application of GABAB receptor-related drugs. In this paper, the specific mechanisms of GABAB
receptors involved in various CNS diseases are reviewed based on the structures and functions of BABAB
receptors. |
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