| 刘艳梅
，孟新玲.T淋巴细胞与阿尔茨海默病相关性的研究进展[J].神经损伤功能重建,2023,(8):484-487 |
| T淋巴细胞与阿尔茨海默病相关性的研究进展 |
| Research Progress on the Correlation between T Lymphocytes and Alzheimer’s Disease |
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| DOI： |
| 中文关键词: 阿尔茨海默病 T淋巴细胞 亚群 研究进展 |
| 英文关键词: Alzheimer’s disease T lymphocytes subset research progress |
| 基金项目:新疆维吾尔自治区
自然科学基金项目
（No. 2022D01C16
1） |
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| 中文摘要: |
| 阿尔茨海默病（AD）是一种中枢神经系统退行性疾病。神经炎症是影响AD进展的关键因素，研究显
示AD患者脑实质内存在外周T淋巴细胞及其亚群的浸润，提示外周免疫细胞可通过血脑屏障并介导和参
与中枢神经炎症的调节，影响AD病程进展。本文将阐述T淋巴细胞及其亚群与AD疾病发展之间的相关
性和研究进展，并概述AD的主要治疗药物与炎症相关性。 |
| 英文摘要: |
| Alzheimer’s disease (AD) is a neurodegenerative disease. Neuroinflammation is a key factor affecting the progression of AD. In recent years, a number of studies have identified the infiltration of peripheral T
lymphocytes and their subsets in the brain parenchyma of AD patients, which confirmed that peripheral immune
cells can cross the blood-brain barrier and participate in the regulation of central neuroinflammation, affecting
the progression of AD. In this review, we will describe the research progress on the correlation between T lymphocytes, their subsets and the development of AD, and summarize the correlation between inflammation and
the main therapeutic drugs for AD. |
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