文章摘要
杨晓敏 ，魏琳 ，叶日春 ，张小培 ，陈捷晗 ，刘竹韵 ，朱灿辉.颈动脉支架成形术后高灌注综合征危险因素的Meta分析[J].神经损伤功能重建,2023,(8):450-455
颈动脉支架成形术后高灌注综合征危险因素的Meta分析
Risk Factors of Hyper-perfusion Syndrome after Carotid Artery Stenting: Meta-analysis
  
DOI：
中文关键词: 颈动脉支架成形术  高灌注综合征  危险因素  Meta分析
英文关键词: carotid artery stenting  hyperperfusion syndrome  risk factors  meta analysis
基金项目:国家卫生健康委科 学技术研究所项目 （No. 2021KYSHX 016010201）
作者单位
杨晓敏1 ，魏琳2 ，叶日春2 ，张小培2 ，陈捷晗2 ，刘竹韵2 ，朱灿辉2 1. 广州中医药大学 第二临床医学院 2. 广州中医药大学 第二附属医院 
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中文摘要:
      目的：系统评价颈动脉支架成形术后高灌注综合征（CHS）的发生率及危险因素。方法：于2023年1月 26日检索Pubmed、Cochrane、Embase、Web of Science、中国生物医学文献数据库、中国知网、万方数据和中国 科技期刊数据库中有关颈动脉支架成形术后 CHS 的病例对照研究和横断面研究。采用 R4.2.1 和 Review Manager 5.3进行Meta分析。结果：共纳入14篇文献，3313例患者。Meta结果示，颈动脉支架成形术后CHS 发生率为 10.0%（95% CI 6%-14%）。糖尿病史 [OR=2.54，95% CI(1.64, 3.95)，P＜0.0001]、重度狭窄[OR= 20.69，95%CI(1.15, 370.72)，P=0.04]、术前脑血管反应性[OR=24.53，95%CI(16.51, 32.55)，P＜0.00001]、后循 环支架[OR=2.96，95% CI(1.31, 6.68)，P=0.009]是颈动脉支架成形术后CHS的危险因素。结论：颈动脉支架 成形术后CHS发生率较高。合并糖尿病、重度狭窄、术前脑血管反应性和后循环支架置入是颈动脉支架成 形术后CHS的重要危险因素。在为这些患者群体计划实施手术及围术期护理时，应充分考虑以上因素。
英文摘要:
      To systematically evaluate the incidence and risk factors of cerebral hyperperfusion syndrome (CHS) after carotid artery stenting. Methods: We retrieved risk factors from eight major databases for case-control studies and cross-sectional studies of CHS after carotid artery stenting in Jan 26, 2023, including Pubmed, Cochrane Library, Embase, Web of Science, China Biomedical Literature Database, China Knowledge Network, Wanfang Data, and Chinese Science and Technology Journal Database. The meta-analysis was performed using R4.2.1 and Review Manager 5.3. Results: A total of 3313 samples were searched and 14 studies were included. Meta-analysis results showed that the incidence of CHS after carotid artery stenting was 10.0% (95% CI 6%-14% ). History of diabetes [OR=2.54, 95% CI(1.64, 3.95), P<0.0001], severe stenosis [OR=20.69, 95% CI(1.15, 370.72), P=0.04], preoperative cerebrovascular reactivity [OR=24.53, 95% CI(16.51, 32.55), P< 0.00001] and rear circulation bracket [OR=2.96, 95% CI(1.31, 6.68), P=0.009] were risk factors for CHS after carotid artery stenting. Conclusion: The meta-analysis showed a higher incidence of CHS after carotid artery stenting. Previous history of diabetes mellitus, severe stenosis, preoperative cerebrovascular reactivity and rear circulation bracket are important risk factors for CHS after carotid artery stenting. These factors should be fully considered in perioperative care for these patient groups.
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