| To evaluate the effect of aerobic exercise on cognitive function in patients with
Parkinson’s disease. Methods: The literature was searched for randomized or non-randomized controlled trials
on the effect of aerobic exercise on cognitive function in patients with Parkinson’s disease. Publications were
then systematically retrieved from PubMed, Embase, Web of Science, The Cochrane Library, PsycINFO, China
National Knowledge Internet, Wanfang, China Science and Technology Journal Database, and SinoMed from
the date of database establishment to May 22, 2022. Meta-analysis was conducted using Stata 17.0 software
after literature screening, data extraction, and quality evaluation. Results: A total of 19 studies were analyzed.
Compared with the control group, patients with Parkinson’s disease who performed aerobic exercise showed
significantly improved average scores of attention (SMD=0.31; 95% CI 0.13～0.50; P<0.001), executive
function (SMD=0.59; 95% CI 0.39～0.78; P<0.001), and memory (SMD=0.43; 95% CI 0.09～0.77; P=0.02).
Conclusion: Aerobic exercise can improve memory, executive function, and attention in patients with
Parkinson's disease, but more high-quality studies are needed to determine the exact amount of exercise needed. |