| A visual analysis of the internationally published literature on stem cell therapy for
ischemic stroke between 2012 and 2021 was performed. Methods: The core collection of Web of Science
citation index database was used as the data source, and CiteSpace software was used to make a visual analysis
of the literature related to stem cell and ischemic stroke between 2012 and 2021 in terms of annual number of
publications, country, institution, author, co-citation, and keywords. Results: A total of 1 941 articles were
included. The United States and China were the countries with the highest number of publications in this field,
and the representative institutions were the University of Florida in the United States and Shanghai Jiao Tong
University in China, respectively. The most prolific team was the one led by Prof. Cesar V Borlongan, a
professor at the University of South Florida College of Medicine. Mesenchymal stem cells, transplantation,
neural stem cells, animal models, functional recovery, regenerative medicine, and nanomaterials were the
research hotspots in this field. According to the time series analysis, research on the action mechanisms of
different types of cells, such as mesenchymal stem cells, neural stem cells, and bone marrow stromal cells was
mainly conducted in the early stage of development; research on implantation of stem cells and recovery of
post-stroke dysfunction was mainly conducted in the middle stage of development; the research on drug
delivery, immunotherapy, and nanomedicine has been focused on from the late stage to the present.
Conclusion: Stem cell therapy for ischemic stroke has broad prospects in the future. |