| 丁鹏锦
，龙显贵
，杨丽霞
，王艺明.加速高频重复经颅磁刺激对伴有自杀意念的青少年抑郁症患者的疗效[J].神经损伤功能重建,2023,(6):325-328 |
| 加速高频重复经颅磁刺激对伴有自杀意念的青少年抑郁症患者的疗效 |
| Efficacy of Accelerated High-frequency Repetitive Transcranial Magnetic Stimulation in Ado⁃lescent Depression with Suicidal Ideation |
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| DOI： |
| 中文关键词: 加速高频重复经颅磁刺激 青少年 抑郁症 自杀意念 |
| 英文关键词: accelerated high-frequency repetitive transcranial magnetic stimulation adolescent depression suicidal ideation |
| 基金项目:黔 科 合 支 撑 项 目
（No. [2020]4Y198） |
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| 中文摘要: |
| 目的：探讨加速高频重复经颅磁刺激（accelerated high-frequency repetitive transcranial magnetic stimulation，aHF-rTMS）对青少年抑郁症患者的疗效及安全性。方法：选取我院精神科57例伴有自杀意念的青
少年抑郁发作患者，随机分为标准组（30例）和加速组（27例）。标准组给予标准重复经颅磁刺激（rTMS）治
疗14 d，加速组给予aHF-rTMS治疗7 d。分别在治疗前（T1）以及治疗后第1周（T2）、第2周（T3）、第4周
（T4）进行汉密尔顿抑郁量表-24项（Hamilton depression scale-24，HAMD-24）、自杀意念量表（scale for suicide ideation，SSI）、临床总体印象量表-疾病严重程度分量表（clinical global impression-severity of illness
scale，CGI-SI）评定。结果：2组T1期HAMD、SSI、CGI-SI量表总分差异无统计学意义（P＞0.05）。与T1期
比较，2组在T4期的HAMD、SSI及CGI-SI分数有不同程度下降（P＜0.05）；与标准组同期比较，加速组SSI
总分在 T2 时下降更为显著（t＝－5.542，P＜0.05）；2 组在 T4 期 HAMD、SSI 及 CGI-SI 差异无统计学意义
（P＞0.05）。T4期时，加速组显效率为77.8%，高于标准组的53.3%，但差异无统计学意义（P＞0.05）。2组
治疗期间不良反应发生率差异无统计学意义（P＞0.05），且未发生严重不良反应。结论：aHF-rTMS治疗可
以改善青少年抑郁症患者的抑郁情绪及自杀意念，其在治疗4周内的疗效及安全性等同于标准rTMS治
疗，而且aHF-rTMS治疗在快速降低患者的自杀意念上更有优势。 |
| 英文摘要: |
| To investigate the efficacy and safety of accelerated high-frequency repetitive transcranial magnetic stimulation (aHF-rTMS) in adolescents with depression. Methods: Fifty-seven adolescent depressive episode patients with suicidal ideation in the psychiatric department of our hospital were selected and assigned to the accelerated and standard groups. The accelerated group received aHF-rTMS for 7 days, and the
standard group received standard rTMS for 14 days. Twenty-four items of the Hamilton Depression Scale
(HAMD-24), Scale for Suicidal Ideation (SSI), and Clinical Global Impression-Severity of Illness (CGI-SI)
were used for evaluation. Results: There were no significant differences in the total scores of the HAMD, SSI,
and CGI-SI scales at T1 between the two groups (P>0.05). Total scores of HAMD, SSI, and CGI-SI at T4 decreased to different degrees in both groups (P<0.05) compared to T1. Total score of SSI in T2 in the accelerated
group decreased more than that in standard group (t=－5.542, P<0.05). There were no significant differences in
the total scores of the HAMD, SSI, and CGI-SI scales at T4 between the two groups (P>0.05). The total significant efficiency in the accelerated group at T4 was 77.8% , which was higher than that in standard group, but
there was no significant differences (P>0.05). There were no significant differences in the incidence of adverse
reactions between the two groups during treatment (P>0.05). Conclusion: aHF-rTMS treatment can improve
depressive mood and suicidal ideation in adolescent patients with depression, and its efficacy and safety within
4 weeks of treatment are the same as those of standard rTMS treatment. Furthermore, aHF-rTMS treatment has
more advantages in rapidly reducing suicidal ideation in patients. |
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