| 柳欣，蔡慧慧，郑元初.红细胞来源α-突触核蛋白作为早发型帕金森病生物标记物的研究[J].神经损伤功能重建,2023,(6):311-315 |
| 红细胞来源α-突触核蛋白作为早发型帕金森病生物标记物的研究 |
| Alpha-Synuclein Species in Red Blood Cells as Biomarkers for Early-onset Parkinson’s Dis⁃ease |
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| DOI： |
| 中文关键词: 红细胞 α-突触核蛋白 早发型帕金森病 生物标记物 |
| 英文关键词: erythrocyte α-synuclein early-onset Parkinson’s disease biomarker |
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| 摘要点击次数: 901 |
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| 中文摘要: |
| 目的：研究早发型（发病年龄＜50岁）帕金森病（PD）患者红细胞中是否存在α-突触核蛋白（α-Syn）异
常沉积，以及红细胞来源α-Syn能否作为早发型PD的生物标志物。方法：早发型PD患者26例纳入早发型
PD组，30例年龄、性别匹配的健康对照受试者纳入对照组；收集所有入组受试者的人口学及临床资料。对
早发型PD组的患者进行国际运动障碍协会统一帕金森病评价量表（MDS-UPDRS）和Hoehn&Yahr（H-Y）
量表、简易精神状态检查量表（MMSE）、蒙特利尔认知评估量表（MoCA）测评。应用电化学发光免疫测定
法检测 2 组红细胞中的α-Syn 单体和α-Syn 聚集体浓度，并分析早发型 PD 患者红细胞来源α-Syn 单体和
α-Syn聚集体浓度与临床指标的相关性。结果：早发型PD患者的α-Syn单体和α-Syn聚集体的水平显著高
于健康对照（P=0.009、P＜0.0001）。在诊断效力方面，红细胞α-Syn聚集体优于α-Syn单体，红细胞α-Syn聚
集体诊断早发型PD的AUC为0.887（95% CI 0.794 - 0.981），敏感度为73.3%，特异度为96.2%。早发型PD
组红细胞来源α-Syn单体和α-Syn聚集体浓度与患者年龄、病程、H-Y分期、MDS-UPDRS-Ⅲ评分、MMSE 评
分、MOCA评分等指标均无显著相关性（P＞0.05）。结论：早发型PD患者红细胞中存在α-Syn异常沉积，红
细胞来源α-Syn特别是α-Syn聚集体可作为早发型PD的生物标志物。 |
| 英文摘要: |
| To investigate the presence of abnormal α-synuclein ( α-Syn) deposition in red blood
cells (RBCs) in patients with early-onset Parkinson’s disease (PD) and determine whether RBC-derived α-Syn
could serve as a biomarker for early-onset PD. Methods: A total of 26 patients with early-onset PD (onset age<
50 years) were included in the early-onset PD group, and 30 age- and sex-matched healthy control participants
were included in the control group (HCs). Demographic and clinical data were collected for all participants. The
Movement Disorder Society-Unified Parkinson’s Disease Rating Scale (MDS-UPDRS), Hoehn and Yahr (H-Y)
scale, Mini-Mental State Examination (MMSE), and Montreal Cognitive Assessment (MoCA) were used to assess the patients in the early-onset PD group. Electrochemiluminescence immunoassay was performed to measure the levels of α-Syn monomers and aggregates in the RBCs of both groups. The correlation between
RBC-derived α-Syn levels and clinical indicators in patients with early-onset PD was analyzed. Results: The
levels of both α-Syn monomers and aggregates in RBCs were significantly higher in patients with early-onset
PD than in HCs (P=0.009, P<0.0001). In terms of diagnostic performance, RBC-derived α-Syn aggregates
showed superior performance over monomers, with an area under the receiver operating characteristic curve
(AUC) of 0.887 (95% CI 0.794-0.981), 73.3% sensitivity, and 96.2% specificity for diagnosing early-onset PD.
The levels of RBC-derived α-Syn monomers and aggregates showed no significant correlation with patient age,
disease duration, H-Y stage, MDS-UPDRS III score, MMSE score, or MoCA score (P>0.05). Conclusion: Abnormal α-Syn deposition was found in the RBCs of patients with early-onset PD. RBC-derived α-Syn, particularly α-Syn aggregates, could serve as a biomarker for early-onset PD. |
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