| 王梦莉，潘晓龙，张婷婷.首发青年重度抑郁症患者脑白质结构网络分析[J].神经损伤功能重建,2023,(5):274-278 |
| 首发青年重度抑郁症患者脑白质结构网络分析 |
| Analysis of the White Matter Structure Network in Treatment-naive Adults with Depression |
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| DOI： |
| 中文关键词: 抑郁症 磁共振 脑网络 图论 |
| 英文关键词: major depression magnetic resonance brain network Graph theory |
| 基金项目:宜昌市医疗卫生研
究项目（No. A20-2-
025） |
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| 摘要点击次数: 902 |
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| 中文摘要: |
| 目的：探讨首发未经治疗青年重度抑郁症患者的脑功能网络变化特征。方法：收集24例首发重度抑
郁症患者（抑郁症组）及年龄、性别、受教育年限相匹配的25例健康志愿者（健康对照组），采用汉密尔顿抑
郁量表（HAMD）对2组进行抑郁严重程度评定，2组均行头颅磁共振弥散张量成像（DTI）扫描，通过图论方
法构建大脑网络，计算相关网络指标，应用Gretna的对模块进行估计，比较2组脑网络属性和模块化特征。
结果：抑郁症组同配性较健康对照组增高（t=2.391，P=0.024）；抑郁症组左侧补充运动区、右侧颞上回的介
中心性值较健康对照组增高（t=2.564，P=0.016；t=2.636，P=0.014）；抑郁症组左侧额上回、左侧颞中回、左侧
枕中回、左侧中央旁小叶的节点效率较健康对照组降低（t=2.038，P=0.049；t=2.174，P=0.046；t=2.262，P=
0.032；t=2.043，P=0.048）；抑郁症组右侧杏仁核、左侧脑岛、左侧缘上回的节点最短路径降低（t=2.079，P=
0.047；t=2.086，P=0.047；t=2.244，P=0.034）。连边分析显示，抑郁症组右侧尾状核、右侧豆状壳核的连边强
度较健康对照组下降（P=0.000；P=0.000）；右侧颞上回的介中心性值与HAMD评分呈负相关（r=－0.635，P=
0.012）。结论：抑郁症组的脑网络发生异常，与抑郁症相关的某些脑区功能发生改变和重组有关，局部脑区
功能可出现代偿。 |
| 英文摘要: |
| To explore the characteristics of the brain function network in treatment-naive young
and middle-aged patients with depression. Methods: Twenty-four patients with major depression and 25
healthy volunteers were enrolled in this study. The severity of depression was assessed using the Hamilton
depression scale (HAMD). All participants underwent DTI scanning, their brain networks were constructed
using the graph theory method, the relevant network indexes were calculated, and the modules were estimated
by Gretna's method. Finally, the brain network attributes and modular characteristics of the two groups were
compared. Results: Compared with the healthy control group, patients with major depression had higher
homozygosity (t=2.391, P=0.024); higher median values of left supplementary motor area and right superior
temporal gyrus (t=2.564, P=0.016); and lower node efficiency of the left superior frontal gyrus, left middle
temporal gyrus, left middle occipital gyrus, and left paracentral lobule. Further, the shortest path of nodes in the
right amygdala, left insula, and left superior marginal gyrus was decreased in patients with major depression (t=
2.038, P=0.049; t=2.174, P=0.046; t=2.262, P=0.032; t=2.043, P=0.048), and edge connectivity analysis showed
that the edge connectivity of the right caudate nucleus and the right lenticular putamen in patients with major
depression was lower than that in healthy controls (P=0.000; P=0.000). Finally, we identified negative
correlations between the median value of right superior temporal gyrus and Hamilton Depression Scale scores
(r =－0.635, P=0.012). Conclusion: The brain network of patients with major depression is abnormal; the
functions of some brain regions related to major depression are altered and show recombination, for which local
brain regions may compensate. |
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