| 江迁，张卓，黄逸民，卢亮，雷霆.肿瘤相关成纤维细胞与垂体瘤的大小、侵袭性、质地及术后垂体功能的相关性[J].神经损伤功能重建,2023,(4):193-196 |
| 肿瘤相关成纤维细胞与垂体瘤的大小、侵袭性、质地及术后垂体功能的相关性 |
| A Study of the Correlation between TAF in Pituitary Tumors and Tumor Size, Invasion, Tex⁃ture, and Postoperative Pituitary Gland Function |
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| DOI： |
| 中文关键词: 垂体瘤 肿瘤相关成纤维细胞 垂体功能减退 |
| 英文关键词: pituitary adenoma tumor-associated fibroblasts hypopituitarismpituitary adenoma tumor-associated fibroblasts hypopituitarism |
| 基金项目:国家自然科学基金
（No. 82173136） |
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| 中文摘要: |
| 目的：探讨垂体瘤中肿瘤相关成纤维细胞（TAF）与肿瘤的大小、侵袭性、质地及术后垂体功能的相关
性。方法：回顾性分析经鼻蝶入路手术切除垂体腺瘤治疗的112例垂体腺瘤患者的临床资料，取其中24例
的垂体腺瘤组织，行免疫组织化学染色检测TAF的3种生物标志物：α-平滑肌肌动蛋白（α-SMA），血小板衍
生生长因子受体（PDGFRB）和转胶蛋白（TAGLN）。根据术后激素水平将患者分为垂体功能减退组和垂体
功能正常组；根据肿瘤质地将患者分为质地韧组和质地软组。分析TAF水平与肿瘤的大小、侵袭性、质地
及术后垂体功能的关系。结果：①与垂体功能正常组相比，垂体功能减退组患者男性比例更高（P＜0.001），
年龄更大（P=0.043），肿瘤更大（P＜0.001），Knosp 分级更高（P=0.041），肿瘤质地韧性比例更高（P＜
0.001）。②与垂体功能正常组相比，垂体功能减退组患者垂体瘤中的α-SMA、PDGFRB和TAGLN阳性比例
明显增高（均P＜0.01）；与质地软组相比，质地韧性组患者垂体瘤中的α-SMA、PDGFRB和TAGLN阳性比
例明显增高（均P＜0.01）。TAF数量与垂体瘤的肿瘤大小（均P＜0.01）和Knosp分级（均P＜0.01）均呈显著
正相关。结论：垂体瘤中的TAF在术后垂体功能减退患者中表达量更高，在肿瘤质地韧的患者中表达量更
高，并且TAF与垂体瘤的大小和侵袭性呈显著正相关。 |
| 英文摘要: |
| To investigate the correlation between tumor-associated fibroblasts (TAF) in pituitary tumor and tumor size, aggressiveness, texture, and postoperative pituitary function. Methods: The clinical data of
112 pituitary adenoma patients treated with pituitary adenoma by transnasal sphenoidal approach surgery was retrospectively analyzed. The pituitary adenoma tissues of 24 cases were collected and immunohistochemical staining was performed to detect three biomarkers of TAF: α-SMA, PDGFRB and TAGLN. Patients were divided into hypopituitarism group and normal function group according to the postoperative hormone test results. And patients were divided into hard texture group and soft texture group according to texture of tumors. The correlation
between TAF in pituitary tumor and tumor size, aggressiveness, texture, and postoperative pituitary function
were analyzed. Results: (1) Compared with the normal function group, the hypopituitarism group had higher
proportion of men, older age, larger tumor size, higher Knosp grading and higher proportion of hard texture (all
P<0.05). (2) Compared with the normal function group, the hypopituitarism group had higher expressions of
α-SMA, PDGFRB and TAGLN (all P<0.01). Compared with the soft texture group, the hard texture group had
higher expressions of α-SMA, PDGFRB and TAGLN (all P<0.01). And expression level of TAF was significantly positively correlated with the size of pituitary tumors and the Knosp grading (all P<0.01). Conclusion: TAF
in pituitary tumor are expressed in higher amounts in patients with hypopituitarism after surgery and in patients
with harder tumor texture. The level of TAF in pituitary tumors is significantly positively correlated with the size
and aggressiveness of pituitary tumors. |
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