董露露
,王璐璐
,王天俊.5-羟色胺递质系统与帕金森病非运动症状的关系研究进展[J].神经损伤功能重建,2023,(3):158-160 |
5-羟色胺递质系统与帕金森病非运动症状的关系研究进展 |
Research Progress of Relationship between the 5-HT Transmitter System and theNon-motor Symptoms of Parkinson's Disease |
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DOI: |
中文关键词: 帕金森病 5-羟色胺 非运动症状 |
英文关键词: Parkinson's disease 5-HT non-motor symptoms |
基金项目:国家自然科学基金
(No. 81241037) |
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中文摘要: |
目前较多研究已揭示帕金森病(PD)运动症状的病理生理机制及治疗,然而针对其非运动症状
(NMS)的形成机制及用药较有限,并且多数患者在确诊前早已出现未受关注的NMS。近年来,国内外研
究发现5-羟色胺(5-HT)与PD-NMS及治疗用药之间存在密切联系。本文就目前常见的NMS与5-HT之
间的关系及治疗用药进行综述。 |
英文摘要: |
More studies have revealed the pathophysiological mechanisms and treatment of motor symptoms
in Parkinson's disease (PD), but the mechanisms and medications for non-motor symptoms (NMS) are more
limited, and most patients develop unattended NMS long before diagnosis. In recent years, domestic and
international studies have identified a strong link between 5-hydroxytryptamine (5-HT) and PD-NMS and the
medication used to treat it. In this paper, we review the current relationship between NMS and 5-HT and its
therapeutic use. |
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