| 蔚文翔，秦川，田代实，王伟.视神经脊髓炎谱系疾病中的脂质代谢异常与疾病活动相关性的研究进展[J].神经损伤功能重建,2023,(2):89-91 |
| 视神经脊髓炎谱系疾病中的脂质代谢异常与疾病活动相关性的研究进展 |
| Research Progress on the Correlation between Lipid Metabolism Abnormalities and DiseaseActivity in Neuromyelitis Optica Spectrum Disorders |
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| DOI： |
| 中文关键词: 视神经脊髓炎 低密度脂蛋白 高密度脂蛋白 甘油三酯 |
| 英文关键词: neuromyelitis optica low density lipoprotein high density lipoprotein triglyceride |
| 基金项目:国家自然科学基金
（No. 81873743） |
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| 中文摘要: |
| 视神经脊髓炎谱系疾病（NMOSD）是中枢神经系统的自身免疫性脱髓鞘疾病。越来越多的证据表
明，脂质代谢与NMOSD的不良临床疾病活动相关。在这篇综述中，我们总结了低密度脂蛋白（LDL）、高密
度脂蛋白（HDL）、甘油三酯（TG）与NMOSD活动性的相关性。虽然NMOSD的疾病活动性与脂质代谢异
常之间的因果关系尚未阐明，但我们认为，这一研究领域的进展有可能提高对视神经脊髓炎病理生理学的
理解，并确定新的治疗目标和策略。 |
| 英文摘要: |
| Neuromyelitis optica spectrum disorders (NMOSD) is an autoimmune demyelinating disease in the
central nervous system. There is increasing evidence that lipid metabolism is associated with adverse clinical
disease activity in NMOSD. In this review, we summarized the correlation between low density lipoprotein
(LDL), high density lipoprotein (HDL), triglyceride (TG) and NMOSD activity. Although the causal relationship
between disease activity in NMOSD and abnormal lipid metabolism has not been elucidated, we believe that
advances in this area of research have the potential to improve understanding of the pathophysiology of
neuromyelitis optica and identify new treatment targets and strategies. |
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