| 张婉婉，刘凤霞，连亚军，刘洪波，谢南昌.类固醇激素治疗前庭神经炎有效性的Meta分析[J].神经损伤功能重建,2022,17(11):632-635 |
| 类固醇激素治疗前庭神经炎有效性的Meta分析 |
| Meta-Analysis on Steroids in Treatment of Vestibular Neuritis |
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| DOI： |
| 中文关键词: 前庭神经炎 类固醇激素 Meta分析 |
| 英文关键词: vestibular neuritis corticosteroids meta-analysis |
| 基金项目:国家自然科学基
金（No. 8197121
4） |
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| 摘要点击次数: 2174 |
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| 中文摘要: |
| 目的：系统评价类固醇激素治疗前庭神经炎的有效性。方法：计算机检索 The Cochrane Library、
PubMed、EMbase、Web of Science、CBM、中国知网、万方及维普数据库，搜集有关类固醇激素治疗前庭神经炎
的随机对照试验（RCT），检索时限均为建库至2020年11月27日。由2名研究者独立筛选文献、提取资料并
评价纳入研究的偏倚风险后，采用RevMan5.4进行Meta分析。结果：共纳入7个RCT，包括294例患者。Meta
分析结果显示：类固醇激素可促进治疗后24 h患者眩晕症状的改善（RR=0.29，95%CI 0.11～0.71，P=0.007）；
但对治疗后1、6月眩晕残障程度评定量表（DHI）评分、治疗后1、6和12月半规管麻痹（CP）程度改善及治疗后
眼震消失的平均天数，2组差异无统计学意义（P＞0.05）。结论：现有证据表明，类固醇激素可促进前庭神经
炎患者发病初期眩晕的恢复；而对半规管轻瘫改善、长期眩晕恢复和眼震消失无促进作用。 |
| 英文摘要: |
| To systematically evaluate the efficacy of steroids in the treatment of vestibular neuritis.
Methods: The Cochrane Library, PubMed, Embase, Web of Science, CBM, CNKI, WanFang Data, and VIP
databases were electronically searched to collect randomized controlled trials (RCTs) on the efficacy of steroids in
the treatment of vestibular neuritis from inception to November 27, 2020. Two reviewers independently screened
literature, extracted data, and assessed the risk of bias of included studies. Then, meta-analysis was performed
using RevMan5.4 software. Results: A total of 7 RCTs were included, including 294 patients. Results of
meta-analysis showed that corticosteroids could promote the improvement of vertigo symptoms 24 hours after
treatment (RR=0.29, 95% CI 0.11～0.71, P=0.007). However, there was no statistical significance between the two
groups in the Dizziness Handicap Inventory (DHI) score at 1 and 6 months after treatment, the improvement of
canal paresis (CP) at 1, 6, and 12 months after treatment, and the mean days of nystagmus disappearance after
treatment (P>0.05). Conclusion: The current evidence shows that corticosteroids can promote the recovery of
vertigo symptoms in the short term in patients with vestibular neuritis. However, they did not improve semicircular
canal function, the recovery of long-term vertigo, and the disappearance of nystagmus. |
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