| 陆飞宇，王文宏，李剑侠，黄先锋，林小祥.高血压脑出血患者血肿周围脑组织miR-146a表达与自噬及短期预后的关系[J].神经损伤功能重建,2022,17(4):199-203 |
| 高血压脑出血患者血肿周围脑组织miR-146a表达与自噬及短期预后的关系 |
| Relationship between Expression of miR-146a in Perihematomal Brain Tissue and Autophagyand Short-term Prognosis in Patients with Hypertensive Intracerebral Hemorrhage |
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| DOI： |
| 中文关键词: 高血压脑出血 miR-146a 自噬 预后 影响因素 |
| 英文关键词: hypertensive intracerebral hemorrhage miR-146a autophagy prognosis influencing factors |
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| 中文摘要: |
| 目的：研究高血压脑出血患者血肿周围脑组织miR-146a表达与自噬及短期预后的关系。方法：在我
院接受血肿清除术并完成术后3个月随访的高血压脑出血患者204例纳入脑出血组，另取尸检的非脑出血
病例18例纳入对照组。收集患者临床资料；检测血肿周围脑组织及对照组正常脑组织中的miR-146a及自
噬基因Beclin-1、组织蛋白酶D（Cathepsin D）、微管相关蛋白1轻链3（LC3）-II/LC-I的表达；脑出血组患者出
院后随访3个月，并根据改良Rankin评分量表评分（mRS）分为预后不良组187例和预后良好组117例；采用
ROC曲线分析miR-146a对预后的预测价值，采用Logistic回归分析预后的影响因素。结果：脑出血组血肿
周围脑组织中miR-146a的表达水平明显低于对照组，自噬基因Beclin-1、Cathepsin D、LC3-II/LC-I的表达水
平明显高于对照组（P＜0.05）且miR-146a与Beclin-1、Cathepsin D、LC3-II/LC-I呈负相关；脑出血组中预后良
好患者与预后不良患者比较，入院时 NIHSS 评分、白细胞计数、入院即刻血糖、血肿体积、破入脑室及
miR-146a、Beclin-1、Cathepsin D、LC3-II/LC-I 表达水平的差异有统计学意义（P＜0.05）；经 ROC 曲线分析，
miR-146a的表达对脑出血组患者的预后具有预测价值；经Logistic回归分析，NIHSS评分、血肿体积、破入脑
室、miR-146a、Beclin-1是脑出血组患者预后的影响因素（P＜0.05）。结论：miR-146a在高血压脑出血的血
肿周围脑组织中低表达且与自噬过度激活、短期预后不良有关。 |
| 英文摘要: |
| To study the relationship between the expression of miR-146a in perihematomal brain tissue and autophagy and short-term prognosis in patients with hypertensive intracerebral hemorrhage(ICH). Meth⁃
ods: A total of 204 patients with hypertensive ICH who underwent hematoma clearance in our hospital and were
followed up for 3 months were selected as the ICH group. Another 18 non-cerebral hemorrhage cases from autopsies were selected as the control group. Clinical data from patients were collected. The expression of miR-146a,
autophagic gene Beclin-1, Cathepsin D, and LC3-II/LC3-I in perihematomal brain tissue and normal brain tissue
was detected. Three months after discharge, the patients in the ICH group were divided into 187 poor prognosis
patients and 117 good prognosis patients based on the modified Rankin Scale (mRS) score. The predictive value
of miR-146a on prognosis was analyzed by ROC curve, and the influencing factors were analyzed by Logistic regression. Results: The expression level of miR-146a in perihematomal brain tissue of the ICH group was significantly lower than that of the control group; the expression levels of autophagy gene Beclin-1, Cathepsin D, and
LC3-II/LC3-I were significantly higher than those of the control group (P<0.05), and miR-146a was negatively
correlated with Beclin-1, Cathepsin D, and LC3-II/LC3-I. The difference in NIHSS score at admission, WBC,
ABG at admission, hematoma volume, ventricular rupture, and expression levels of miR-146a, Beclin-1, Cathepsin D, and LC3-II/LC3-I
between poor prognosis patients and good prognosis patients in ICH group were statistically significance (P<0.05). ROC curve analysis
showed that the expression of miR-146a had predictive value for the prognosis of patients with ICH; Logistic regression analysis showed
that the NIHSS score, hematoma volume, ventricular rupture, miR-146a, and Beclin-1 were the influencing factors for prognosis in the
ICH group (P<0.05). Conclusion: Expression of miR-146a decreases in the perihematomal brain tissue following hypertensive ICH and
is related to the hyperactivity of autophagy and poor short-term prognosis. |
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