| 顾俊怡*，薛光仁*，李海波，虞正权，周幽心，陈罡，王中.神经导航显微镜下经鼻蝶垂体瘤切除术的疗效观察[J].神经损伤功能重建,2022,17(3):131-134 |
| 神经导航显微镜下经鼻蝶垂体瘤切除术的疗效观察 |
| Effect of Neuronavigation-Assisted Microscopic Transsphenoidal Resection in Patients withPituitary Adenoma |
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| DOI： |
| 中文关键词: 垂体肿瘤 神经导航 显微镜 垂体瘤切除术 激素水平 视觉功能 |
| 英文关键词: pituitary adenoma neuronavigation microscope pituitary adenoma resection hormone levels visual function |
| 基金项目:国家自然科学基金
（No. 81671743） |
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| 摘要点击次数: 1956 |
| 全文下载次数: 2025 |
| 中文摘要: |
| 目的：探讨神经导航显微镜下经鼻蝶垂体瘤切除术对患者自体功能相关激素水平及视觉功能的影
响。方法：垂体瘤患者87例，根据手术时间分为对照组42例、观察组45例。对照组采用神经内镜经鼻蝶垂
体瘤切除术，观察组采用神经导航显微镜下经鼻蝶垂体瘤切除术。随访1月，比较2组手术相关指标、垂体
功能相关激素水平、视觉功能、并发症等。结果：观察组的手术时间、住院时间短于对照组，出血量大于对照
组（P＜0.05或P＜0.01）；促甲状腺激素（TSH）、游离三碘甲状腺原氨酸（FT3）、促肾上腺皮质激素（ACTH）、
泌乳素（PRL）明显高于对照组，皮质醇（COR）明显低于对照组（均P＜0.05）；视野平均缺损（MD）值、视野模
式标准差（PSD）低于对照组，视野指数（VFI）高于对照组（P＜0.05或P＜0.01）；2组脑脊液漏等并发症比较
差异无统计学意义（P＞0.05）。结论：神经导航显微镜下经鼻蝶垂体瘤切除术有助于促进患者垂体功能相
关激素水平恢复，改善视觉功能。 |
| 英文摘要: |
| To study effect of neuronavigation-assisted microscopic transsphenoidal resection on
autonomic function related hormone levels and visual function in patients with pituitary adenoma. Methods: A
total of 87 patients with pituitary adenoma were divided into the observation group (45 cases) and control group
(42 cases). The control group underwent neuroendoscope-assisted endoscopic transsphenoidal resection, and the
observation group underwent neuronavigation-assisted microscopic transsphenoidal resection. Patients were
followed up for 1 month, and surgery-related indexes, pituitary function-related hormone levels, visual function,
and complications were compared between the two groups. Results: The observation group's operation time
and hospital stay were significantly shorter and blood loss was significantly greater than those of the control
group (P<0.05, P<0.01). Thyroid stimulating hormone (TSH), free T3 (FT3), adrenocorticotropic hormone
(ACTH), and prolactin (PRL) levels were significantly higher and cortisol (COR) level was significantly lower
in the observation group than in the control group (all P<0.05). Mean defect (MD) and pattern standard deviation
(PSD) of the visual field were significantly lower and visual field index (VFI) was significantly higher in the
observation group than in the control (P<0.05, P<0.01). There was no significant difference between the two
groups in cerebrospinal fluid leakage and complications (P>0.05). Conclusion：Neuronavigation-assisted
microscopic transsphenoidal resection helps to promote the recovery of pituitary function-related hormone levels
and improve visual function. |
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