文章摘要
郭晋瑜 ，赵娅蓉 ，吕亮亮 ，王童 ，许斐 ，张肖南 ，李阳.一种新型认知训练方法对轻度认知障碍患者各认知域功能的影响[J].神经损伤功能重建,2022,17(1):17-22
一种新型认知训练方法对轻度认知障碍患者各认知域功能的影响
Improvement of Cognitive Domain Function in Patients with Mild Cognitive Impairment by ANew Cognitive Training Method
  
DOI：
中文关键词: 认知训练  轻度认知障碍  认知域功能  综合干预  MoCA指数
英文关键词: cognitive training  mild cognitive impairment  recognition domain functions  integrated interventions  MoCA index
基金项目:中央引导地方科技 发展专项资金项目 （YDZX201914000 02563）
作者单位
郭晋瑜1 ，赵娅蓉2 ，吕亮亮1 ，王童1 ，许斐1 ，张肖南1 ，李阳2 1. 山西医科大学第 一临床医学院 2. 山西医科大学第 一医院神经内科 
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中文摘要:
      目的：探讨一种新型认知训练方法对轻度认知障碍患者各认知域功能改善的情况。方法：收集简易 智能精神状态检查量表（MMSE）＞24分，蒙特利尔认知评估量表（MoCA）≤25分，临床痴呆量表为0.5分的 MCI患者102例，随机分为训练组和对照组各51例，2组均给予健康宣教并进行痴呆危险因素的控制，训练 组还通过一种新型认知训练方法进行系统性训练3月。在基线期（训练前）、访视期1（训练3月后）、访视期 2（训练6月后），用MoCA和MoCA认知域指数得分（CDIS）进行评价。结果：训练组不同时间点的MoCA、 MoCA MIS、MoCA EIS、MoCA VIS、MoCA LIS和MoCA AIS等量表评分差异均有统计学意义（P＜0.05）；对 照组患者不同时间点的MoCA量表评分差异有统计学意义（P＜0.05）；训练组的MoCA、MoCA VIS、MoCA LIS和MoCA AIS等量表评分在访视期1和基线期相比差异均有统计学意义（P＜0.05）；训练组的MoCA、 MoCA EIS、MoCA VIS、MoCA LIS和MoCA AIS等量表评分在访视期2与基线期相比差异均有统计学意义 （P＜0.05）；训练组的MoCA、MoCA MIS和MoCA EIS等量表评分在访视期2与访视期1相比差异均有统计 学意义（P＜0.05）；对照组仅有MoCA量表评分在访视期2与基线期相比差异有统计学意义（P＜0.05）；同时 间点，训练组的MoCA和MoCA EIS评分与对照组比较差异均有统计学意义（P＜0.05）。结论：该新型认知 训练方法可显著改善MCI患者的整体认知功能和各认知域情况。
英文摘要:
      To investigate improvement of cognitive domain function in patients with mild cognitive impairment (MCI) by a new cognitive training method. Methods: Total 102 MCI patients with a MMSE score > 24, MoCA score ≤25, and clinical dementia scale of 0.5. Patients were randomly divided into the training group and control group with 51 patients in each. Both groups were given health education and controlled for dementia risk factors. Additionally, the training group underwent systematic training through a new cognitive training method for 3 months. Patients were evaluated at baseline (pre-training), visit 1 (3 months after training), and visit 2 (6 months after training) using the MoCA and MoCA Cognitive Domain Index Score (CDIS) scores. Results: The MoCA, MoCA MIS, MoCA EIS, MoCA VIS, MoCA LIS, and MoCA AIS scores in the training group at different timepoints were significantly different (P<0.05). There were significant differences in the MoCA scores at different timepoints in the control group (P<0.05). In the training group, the MoCA, MoCA VIS, MoCA LIS, and MoCA AIS scores at visit 1 were statistically different from those at baseline (P<0.05); the MoCA, MoCA EIS, MoCA VIS, MoCA LIS, and MoCA AIS scores at visit 2 were statistically different from those at baseline (P<0.05); the MoCA, MoCA MIS, and MoCA EIS scores at visit 2 were statistically different from those at visit 1 (P<0.05). In the control group, only the MoCA scale scores were significantly different at visit 2 compared to baseline (P<0.05). There was a significant difference in the MoCA and MoCA EIS scores between the training group and control group at each timepoint (P<0.05). Conclusion: This new cognitive training method can significantly improve the overall cognitive function and that of each cognitive domain in MCI patients.
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