| 孙思琦，陈国鹏，周恩奇，刘忠纯.衰老对应激前后小鼠抑郁及焦虑样行为的影响[J].神经损伤功能重建,2022,17(1):4-8 |
| 衰老对应激前后小鼠抑郁及焦虑样行为的影响 |
| Effect of Aging on Depressive-Like and Anxiety-Like Behaviors in Mice before and afterStress |
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| DOI： |
| 中文关键词: 衰老 抑郁 焦虑 快感缺失 |
| 英文关键词: age depression anxiety anhedonia |
| 基金项目:国家重点研发计划
（No. 2018YFC131
4600）；
国家自然科学基金
（No. 81771472） |
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| 摘要点击次数: 2548 |
| 全文下载次数: 5860 |
| 中文摘要: |
| 目的：探讨不同年龄段小鼠应激造模前后的抑郁及焦虑样行为。 方法：54只C57BL/6J小鼠分为正常
对照（NC）组和慢性束缚应激（CRS）组，再根据年龄分为青年亚组、中年亚组、老年亚组，共6亚组，每亚组9 只。通过检测各组小鼠的行为学改变，包括体质量、悬尾试验、强迫游泳试验、糖水偏好试验、开放旷场实
验，观察小鼠抑郁样及焦虑样行为。 结果：NC组中，与青年亚组相比，中年亚组小鼠直立次数减少（P＜ 0.05），老年亚组小鼠体质量升高（P＜0.05），悬尾、强迫游泳的不动时间下降（P＜0.05），旷场中移动的总距
离下降、直立次数减少（P＜0.05）；与NC组各亚组相比，CRS组对应各亚组的体质量下降（P＜0.05），悬尾、
强迫游泳的不动时间上升（P＜0.05），糖水偏好率、旷场移动总距离、直立次数均下降（P＜0.05），其中与CRS
组青年亚组相比，老年亚组的悬尾、强迫游泳的不动时间升高（P＜0.05），糖水偏好率下降（P＜0.05），旷场
直立次数下降（P＜0.05）。 结论：正常衰老状态下，小鼠年龄越小越容易出现绝望行为，年龄越大焦虑样
行为越严重；应激衰老状态下，小鼠年龄越大，抑郁焦虑样行为程度越严重，特别是奖赏功能受损导致的快
感缺失。 |
| 英文摘要: |
| To explore the depressive-like and anxiety-like behavior of mice at different ages before
and after modeling. Methods: A total of 54 C57BL/6J mice were divided into the normal control (NC) group
and chronic restraint stress (CRS) group, and each group was divided into 3 subgroups according to age,
including young subgroup, middle-aged subgroup, and old subgroup, for a total of 6 subgroups with 9 mice in
each. The behavioral changes of mice in each group were studied through assessing the body weight, tail
suspension test, forced swimming test, sugar preference test, and open field test to evaluate the depressive-like
and anxiety-like behavior of the mice. Results: Within the NC group, compared with that of the young
subgroup, the frequency of rearing behavior of the middle-aged subgroup was significantly decreased (P<0.05);
the body weight of the old subgroup was significantly increased (P<0.05), the immobility time during tail
suspension and forced swimming was significantly decreased (P<0.05), and the total distance traveled and
frequency of rearing behavior in the open field were significantly decreased (P<0.05). Compared with that of the
NC group, body weight of all subgroups in the CRS group was significantly decreased (P<0.05); immobility time
during tail suspension and forced swimming was significantly increased (P<0.05); and sugar preference rate and
the total distance traveled and frequency of rearing behavior in the open field were significantly decreased (P< 0.05). Within the CRS group, compared to that of the young subgroup, the immobility time during tail
suspension and forced swimming in the old subgroup was significantly increased (P<0.05); the sugar preference
rate was significantly decreased (P<0.05); and the frequency of rearing behavior in the open field was
significantly decreased (P<0.05). Conclusion: With normal aging, the younger the mice, the more likely they
were to show behaviors of despair; the older the mice, the more severe were their behaviors of anxiety. With
stress-related aging, the older the mice, the more serious was their depressive-like and anxiety-like behavior,
especially that of anhedonia caused by impairment of the reward function. |
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