文章摘要
刘春燕 ，刘俊华.认知抑郁情绪障碍与脑小血管病总体负担的相关性分析[J].神经损伤功能重建,2021,16(12):710-713
认知抑郁情绪障碍与脑小血管病总体负担的相关性分析
Correlation Analysis of Total Burden Score of Cerebral Small Vessel Disease and CognitiveDysfunction and Depression
  
DOI：
中文关键词: 脑小血管病总体负担  认知功能障碍  抑郁情绪
英文关键词: total burden score of cerebral small vessel disease  cognitive dysfunction  depression
基金项目:山东省菏泽市立医 院科技发展计划项 目（No. 2019YN44）
作者单位
刘春燕a ，刘俊华b 山东省菏泽市立医 院 a.神经内科，b. 核磁共振室 
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中文摘要:
      目的：分析认知抑郁情绪障碍与脑小血管病（CSVD）总体负担的相关性。方法：172例轻型卒中患者 纳入研究，根据核磁共振影像检查结果采用CSVD总负担评分方法评分并分组；分析各组影像学特征；3个 月后随访，采用蒙特利尔认知评估量表（MoCA）和汉密尔顿抑郁量表17项（HAMD-D17）评分分别评定患者 的认知水平和抑郁程度，并进行统计学分析。结果：根据 CSVD 总负担评分，纳入轻度组 37 例，中度组 101例，重度组34例。与轻度组比较，中、重度组患者年龄、高血压病比例和低密度脂蛋白胆固醇水平均较 高（均P＜0.05）；与轻度组相比，中、重度组的MoCA总分、视空间与执行能力和延迟记忆得分较低（均P＜ 0.05），重度组记忆和语言得分较低（均 P＜0.05）；与轻度组相比，中、重度组的 HAMD 评分较高（均 P＜ 0.05）。CSVD总负担评分与MoCA评分呈负相关（r=－0.512，P＜0.05），与HAMD评分呈正相关（r=0.314， P＜0.05）；HAMD评分与MoCA评分呈负相关（r=－0.418，P＜0.05）。结论：CSVD患者的CSVD总负担评 分越高，认知抑郁情绪障碍越重。
英文摘要:
      To explore the correlation between the total burden score of cerebral small vascular disease (CSVD) and cognitive dysfunction and depressive mood disorder. Methods: We selected 172 patients with mild stroke for the study. According to MRI examination results, the total CSVD burden score was obtained and used to divide patients into groups. The imaging characteristics of each group were analyzed. Patients were followed up after 3 months, and cognitive function and depression were assessed by the Montreal Cognitive Assessment Scale (MoCA) and Hamilton Depression Scale 17 (HAMD-D17), respectively. The data were statistically analyzed. Results: According to the total CSVD burden score, 37 patients were placed in the mild group, 101 in the moderate group, and 34 in the severe group. Compared with the mild group, the moderate and severe group patients showed a higher age, hypertension rate, and low-density lipoprotein level (all P<0.05); the moderate and severe groups showed a lower MoCA total score, visuospatial ability score, executive function score, and delayed memory score (all P<0.05), and the severe group displayed lower memory and language function scores (all P<0.05); the moderate and severe groups exhibited higher HAMD scores (all P<0.05). The total CSVD burden score was negatively correlated with the MoCA score (r=－0.512, P<0.05) and positively correlated with the HAMD score (r=0.314, P<0.05). The HAMD score was negatively correlated with the MoCA score (r=－0.418, P<0.05). Conclusion: In CSVD patients, the higher the total CSVD burden score, the more severe the cognitive depressive mood disorder.
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