| 韩超，
，余勤薇
，孙雅迪
，吴佳薇
，李雲娜
，黄金莎.华中地区汉族人群SREBF1基因多态性与帕金森病的相关性分析[J].神经损伤功能重建,2021,16(10):569-571 |
| 华中地区汉族人群SREBF1基因多态性与帕金森病的相关性分析 |
| Correlation between SREBF1 Gene Polymorphism and Parkinson’s Disease in the Han Popula⁃tion of Central China |
| |
| DOI： |
| 中文关键词: 帕金森病 基因多态性 SREBF1基因 rs11868035位点 |
| 英文关键词: Parkinson’s disease gene polymorphisms SREBF1 gene rs11868035 |
| 基金项目:国家重点研发计
划（No. 2017YF
C1310200）；
中国睡眠研究会
豪 森 科 研 项 目
（No. 2019HSA0 2）；
安徽省自然科学
基金（No. 20080
85QH366）；
中央高校基本科
研业务费专项资
金（No. WK9110
000081） |
|
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| 中文摘要: |
| 目的：探索华中地区SREBF1基因突变位点SNP rs11868035与帕金森病（PD）的相关性。方法：本研究
纳入 471 例华中地区原发性 PD 患者和 536 例健康对照者，均为汉族。检测 PD 组和对照组及各亚组间
rs11868035位点等位基因和基因型频率。行文献检索及Meta分析，进一步探索rs11868035位点变异与中国
人群PD易患性的关联。结果：SNP rs11868035位点共3种基因型（AA/AG/GG）；PD组与对照组、各亚组之间
等位基因频率差异、基因型差异无统计学意义（P＞0.05）。Meta分析结果示该位点与中国人群PD发病可能
无明显相关性。结论：华中地区汉族人群SREBF1基因突变位点rs11868035与PD发病可能无相关性。 |
| 英文摘要: |
| To explore the correlation of the SREBF1 gene SNP rs11868035 with Parkinson’s disease
(PD) in the Han population of central China. Methods: We included 471 patients with idiopathic PD and 536
healthy controls, all of Han ethnicity, in this study, and compared the rs11868035 allele and genotype frequency
differences between the two groups. A meta-analysis was conducted to further evaluate the correlation between
rs11868035 and the incidence of PD in the Chinese population. Results: There were 3 genotypes (AA/AG/GG) of
SNP rs11868035. There was no significant difference in allele frequency nor genotype between the PD group and
control group (P>0.05). The meta-analysis showed that there might be no significant correlation between this site
and PD incidence in the Chinese population. Conclusion: The SREBF1 gene SNP rs11868035 might not be correlated with the incidence of PD in the Han population of central China. |
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