| 余伟,
，丁立
，陈玉倩
，吴向锋
，陈俊.小檗碱改善5XFAD小鼠抑郁和焦虑[J].神经损伤功能重建,2021,16(9):497-501 |
| 小檗碱改善5XFAD小鼠抑郁和焦虑 |
| Effect of Berberine on Depression and Anxiety in 5XFAD Mice |
| |
| DOI： |
| 中文关键词: 阿尔茨海默病 小檗碱 5XFAD小鼠 抑郁 焦虑 |
| 英文关键词: Alzheimer's disease berberine 5XFAD mice depression anxiety |
| 基金项目:湖北省卫生健康委
员会面上项目（No.
ZY2019M047）；
十堰市科学技术研
究与开发项目（No.
2020K52） |
|
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| 中文摘要: |
| 目的：明确小檗碱对5XFAD阿尔茨海默病（AD）转基因小鼠的抑郁和焦虑有无改善作用。方法： 将48只3月龄的5XFAD AD转基因小鼠随机分为对照组、小檗碱低剂量组（50 mg/kg）、小檗碱中剂量组
（100 mg/kg）和小檗碱高剂量组（150 mg/kg），每组12只，连续灌胃90 d，利用旷场实验、高架十字迷宫实
验、悬尾实验和强迫游泳实验检测5XFAD小鼠行为学指标的变化。结果：与对照组比较，小檗碱低剂量
组的强迫游泳不动时间和悬尾不动时间减少，高架十字迷宫开放臂停留时间和运动总路程增加（P< 0.05）；小檗碱中剂量组的强迫游泳不动时间和悬尾不动时间减少，高架十字迷宫开放臂停留时间、开放
臂进入次数、运动总路程增加，旷场中央区时间和中央区路程增加（P<0.01）；小檗碱高剂量组的强迫游泳
不动时间和悬尾不动时间减少，高架十字迷宫开放臂停留时间和开放臂进入次数增加，旷场中央区时间
增加（P<0.05）。其中，中剂量小檗碱的效果最明显。结论：小檗碱能改善5XFAD小鼠的抑郁和焦虑。 |
| 英文摘要: |
| To determine whether berberine could improve depression and anxiety in 5XFAD
Alzheimer’s disease (AD) model mice. Methods: A total of 48 3-month-old 5XFAD transgenic AD model
mice were randomly allocated into 4 groups with 12 mice in each: control group, low-dose berberine group
(50 mg/kg), medium-dose berberine group (100 mg/kg), and high-dose berberine group (150 mg/kg). Mice
were given intragastric administrations of berberine every day for 90 days. The changes in behavior indicators
of the 5XFAD mice were observed by the open field test, elevated plus maze test, tail suspension test, and
forced swimming test. Results: Compared with the control group, the low-dose berberine group showed
decreased forced swimming time, decreased tail suspension time, increased time spent in open arms of the
elevated plus maze, and increased total distance traveled in the elevated plus maze (P<0.05); the medium-dose
berberine group showed decreased forced swimming time, decreased tail suspension time, increased time
spent in open arms of the elevated plus maze, increased open arm entries in the elevated plus maze, increased
total distance traveled in the elevated plus maze, increased time spent in the central area of the open field, and
increased distance traveled in the central area of the open field (P<0.01); the high-dose berberine group
showed decreased forced swimming time, decreased tail suspension time, increased time spent in open arms
of the elevated plus maze, increased open arm entries in the elevated plus maze, and increased time spent in
the central area of the open field (P<0.05). Moreover, the effect of medium-dose berberine was the most
apparent. Conclusion: Berberine could improve depression and anxiety in 5XFAD mice. |
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